Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10500470" target="_blank" >RIV/00179906:_____/25:10500470 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/25:00384616 RIV/00216208:11150/25:10500470

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hPP.9-fsyW" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hPP.9-fsyW</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/apa.70253" target="_blank" >10.1111/apa.70253</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data

Popis výsledku v původním jazyce

Aim: This study evaluated urinary calcium (Ca) and phosphorus (P) excretion in very low birth weight infants ( &lt; 1500 g, VLBW) without severe morbidity, treated with methylxanthines. Methods: Eighty-one VLBW infants were analysed. Urinary Ca and P and their creatinine ratios were measured biweekly until day 56. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH)D], total Ca, P and alkaline phosphatase (ALP) were assessed. Bone densitometry was performed before discharge. Results: In 254 urine samples, urinary Ca and P excretion differed significantly from their creatinine ratios. Vitamin D status influenced urinary mineral excretion, likely via PTH regulation, but did not affect serum Ca, P, or ALP. Normative data were established only for infants with serum 25-(OH)D &gt; 50 nmol/L. Due to age-related variability, a single reference range was not possible. Conclusions: We provide age-specific normative data for urinary Ca and P excretion in healthy VLBW infants with sufficient vitamin D. Urinary mineral excretion varies significantly with postnatal age, emphasising the need for individualised monitoring to prevent metabolic bone disease of prematurity. Vitamin D status is crucial for calcium-phosphorus homeostasis, with sufficient levels linked to increased Ca excretion and relative P depletion from the 2 month of life.

Název v anglickém jazyce

Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data

Popis výsledku anglicky

Aim: This study evaluated urinary calcium (Ca) and phosphorus (P) excretion in very low birth weight infants ( &lt; 1500 g, VLBW) without severe morbidity, treated with methylxanthines. Methods: Eighty-one VLBW infants were analysed. Urinary Ca and P and their creatinine ratios were measured biweekly until day 56. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH)D], total Ca, P and alkaline phosphatase (ALP) were assessed. Bone densitometry was performed before discharge. Results: In 254 urine samples, urinary Ca and P excretion differed significantly from their creatinine ratios. Vitamin D status influenced urinary mineral excretion, likely via PTH regulation, but did not affect serum Ca, P, or ALP. Normative data were established only for infants with serum 25-(OH)D &gt; 50 nmol/L. Due to age-related variability, a single reference range was not possible. Conclusions: We provide age-specific normative data for urinary Ca and P excretion in healthy VLBW infants with sufficient vitamin D. Urinary mineral excretion varies significantly with postnatal age, emphasising the need for individualised monitoring to prevent metabolic bone disease of prematurity. Vitamin D status is crucial for calcium-phosphorus homeostasis, with sufficient levels linked to increased Ca excretion and relative P depletion from the 2 month of life.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Paediatrica

ISSN

0803-5253

e-ISSN

1651-2227

Svazek periodika

114

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

3267-3278

Kód UT WoS článku

001543585400001

EID výsledku v databázi Scopus

2-s2.0-105012275633