Evaluation of novel surfactants for the decontamination of chemical warfare agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10506739" target="_blank" >RIV/00179906:_____/25:10506739 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/26:00566019

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4OKhJN-rmX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4OKhJN-rmX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15376516.2025.2554912" target="_blank" >10.1080/15376516.2025.2554912</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of novel surfactants for the decontamination of chemical warfare agents

Popis výsledku v původním jazyce

The decontamination of chemical warfare agents or compounds involved in chemical industry incidents poses a significant challenge to environmental protection and human health. These compounds are highly toxic and could be relatively resistant to conventional decontamination methods. In recent years, surfactants have emerged as a promising option, as they can enhance the solubility of organophosphorus compounds in aqueous solutions while promoting their degradation or adsorption onto surfaces. In this study, 35 compounds (surfactants based on quartenary ammonium salts) were tested using the model pesticide fenitrothion, with the compounds from the 43 C series (quaternary ammonium salts with two hydroxyl functional groups) showing the highest decontamination potential. The 43 C series compounds were further tested in vitro for the degradation of nerve agents sarin, soman, and VX, as well as the blistering agent sulfur mustard. The compounds labeled 43C14 and 43C16 (benzoxonia with the 14- and 16-carbon chains) exhibited the best potential. Due to the possible use in protective applications for military personnel, an in vivo acute skin irritation test on 43C14 and 43C16 was also conducted in rats. No skin pathology was observed after a 4-h application and during the subsequent 72-h observation period, suggesting its potential for practical use.

Název v anglickém jazyce

Evaluation of novel surfactants for the decontamination of chemical warfare agents

Popis výsledku anglicky

The decontamination of chemical warfare agents or compounds involved in chemical industry incidents poses a significant challenge to environmental protection and human health. These compounds are highly toxic and could be relatively resistant to conventional decontamination methods. In recent years, surfactants have emerged as a promising option, as they can enhance the solubility of organophosphorus compounds in aqueous solutions while promoting their degradation or adsorption onto surfaces. In this study, 35 compounds (surfactants based on quartenary ammonium salts) were tested using the model pesticide fenitrothion, with the compounds from the 43 C series (quaternary ammonium salts with two hydroxyl functional groups) showing the highest decontamination potential. The 43 C series compounds were further tested in vitro for the degradation of nerve agents sarin, soman, and VX, as well as the blistering agent sulfur mustard. The compounds labeled 43C14 and 43C16 (benzoxonia with the 14- and 16-carbon chains) exhibited the best potential. Due to the possible use in protective applications for military personnel, an in vivo acute skin irritation test on 43C14 and 43C16 was also conducted in rats. No skin pathology was observed after a 4-h application and during the subsequent 72-h observation period, suggesting its potential for practical use.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/NW25-08-00088" target="_blank" >NW25-08-00088: Antimikrobiální 3D tisknutelné kalciofosfátové cementy s přísadou kvartérních amoniových solí: Vývoj biokompatibilního samodezinfekčního materiálu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology Mechanisms and Methods

ISSN

1537-6516

e-ISSN

1537-6524

Svazek periodika

35

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1588-1601

Kód UT WoS článku

001566068300001

EID výsledku v databázi Scopus

2-s2.0-105015586813