Efficacy of antidiabetic plants available in Himachal Pradesh in management of diabetes: a comprehensive review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10514643" target="_blank" >RIV/00179906:_____/25:10514643 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18470/25:50021467

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-vuxMa9upb" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-vuxMa9upb</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-024-09971-7" target="_blank" >10.1007/s11101-024-09971-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy of antidiabetic plants available in Himachal Pradesh in management of diabetes: a comprehensive review

Popis výsledku v původním jazyce

Diabetes is a condition that affects metabolism of carbohydrates, sugars, proteins, and lipids. Chronic hyperglycemia caused by abnormalities in insulin secretion or insulin activity is its key characteristic. A severe threat to human health is posed by the rapidly rising prevalence of diabetes mellitus worldwide. Despite the availability of well-known anti-diabetic medications diabetes, and its associated complications, it remains a serious health concern. A severe threat to human health is posed by the rapidly rising prevalence of diabetes mellitus worldwide. This review examines antidiabetic properties of medicinal plants found in Himachal Pradesh, exploring their phytoconstituents and their potential role in managing diabetes mellitus. It collates in vivo and toxicological studies along with clinical trials on various plant species, found in Himachal Pradesh scrutinizing the bioactive compounds that exhibit antidiabetic effects. Results of these studies indicate that specific plant species can significantly reduce blood glucose levels in streptozotocin and alloxan monohydrate-induced diabetic animal models, including male Wistar rats and male Albino mice, over treatment periods ranging from 5 to 49 days. Furthermore, in human clinical settings, the antidiabetic effects of these plants in diabetic patients are investigated within 4 h to 3 months. Changes in biological parameters brought after treatment with these plant extracts are compared to diabetic animals and patients receiving no treatment. These findings underscore the therapeutic potential of Himachal Pradesh&apos;s flora in managing and treating diabetes, advocating for further scientific validation and development of plant-based antidiabetic medications. [GRAPHICS] .

Název v anglickém jazyce

Efficacy of antidiabetic plants available in Himachal Pradesh in management of diabetes: a comprehensive review

Popis výsledku anglicky

Diabetes is a condition that affects metabolism of carbohydrates, sugars, proteins, and lipids. Chronic hyperglycemia caused by abnormalities in insulin secretion or insulin activity is its key characteristic. A severe threat to human health is posed by the rapidly rising prevalence of diabetes mellitus worldwide. Despite the availability of well-known anti-diabetic medications diabetes, and its associated complications, it remains a serious health concern. A severe threat to human health is posed by the rapidly rising prevalence of diabetes mellitus worldwide. This review examines antidiabetic properties of medicinal plants found in Himachal Pradesh, exploring their phytoconstituents and their potential role in managing diabetes mellitus. It collates in vivo and toxicological studies along with clinical trials on various plant species, found in Himachal Pradesh scrutinizing the bioactive compounds that exhibit antidiabetic effects. Results of these studies indicate that specific plant species can significantly reduce blood glucose levels in streptozotocin and alloxan monohydrate-induced diabetic animal models, including male Wistar rats and male Albino mice, over treatment periods ranging from 5 to 49 days. Furthermore, in human clinical settings, the antidiabetic effects of these plants in diabetic patients are investigated within 4 h to 3 months. Changes in biological parameters brought after treatment with these plant extracts are compared to diabetic animals and patients receiving no treatment. These findings underscore the therapeutic potential of Himachal Pradesh&apos;s flora in managing and treating diabetes, advocating for further scientific validation and development of plant-based antidiabetic medications. [GRAPHICS] .

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytochemistry Reviews

ISSN

1568-7767

e-ISSN

1572-980X

Svazek periodika

24

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

33

Strana od-do

739-771

Kód UT WoS článku

001216054000001

EID výsledku v databázi Scopus

2-s2.0-85192805379