Detailed Mapping of Methylcytosine Positions at the CpG Island Surrouding the Pa Promoter at the bcr-abl Locus in CML Patients and Two Cell Lines, K562 and BV173.

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209627%3A_____%2F00%3A00000023" target="_blank" >RIV/00209627:_____/00:00000023 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Detailed Mapping of Methylcytosine Positions at the CpG Island Surrouding the Pa Promoter at the bcr-abl Locus in CML Patients and Two Cell Lines, K562 and BV173.
Popis výsledku v původním jazyce
In most CML cases, one of two abl promoters (Pa) is nested within the bcr-abl transcription unit, but appears to be silent. Recently de novo methylation of the Pa region and its correlation with disease progression were reported. As these previous studies were limited to the use of metylation-sensitive restriction endonucleases, our aim here was to obtain a cpmplete map of methylcytosines and its variants in CML patients in model cell lines.
Název v anglickém jazyce
Detailed Mapping of Methylcytosine Positions at the CpG Island Surrouding the Pa Promoter at the bcr-abl Locus in CML Patients and Two Cell Lines, K562 and BV173.
Popis výsledku anglicky
In most CML cases, one of two abl promoters (Pa) is nested within the bcr-abl transcription unit, but appears to be silent. Recently de novo methylation of the Pa region and its correlation with disease progression were reported. As these previous studies were limited to the use of metylation-sensitive restriction endonucleases, our aim here was to obtain a cpmplete map of methylcytosines and its variants in CML patients in model cell lines.

Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Rok uplatnění
2000
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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