X-linked agammaglobulinemia in community-acquired pneumonia cases reveaeled by immunoglobulin level screening at hospital admission

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F13%3A%230000275" target="_blank" >RIV/00209775:_____/13:#0000275 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1055/s-0033-1354415" target="_blank" >http://dx.doi.org/10.1055/s-0033-1354415</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0033-1354415" target="_blank" >10.1055/s-0033-1354415</a>

Jazyk výsledku

angličtina

Název v původním jazyce

X-linked agammaglobulinemia in community-acquired pneumonia cases reveaeled by immunoglobulin level screening at hospital admission

Popis výsledku v původním jazyce

In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare,some of the infections seen in immunodeficient patients are common. Defective antibody production represents the largest group among these disorders, with otitis, sinusitis and pneumonia as the most frequent initial manifestation. We performed a prospective study of humoralimmunity in children hospitalized due to community-acquired pneumonia in tertiary care hospital. Out of 254 patients (131 boys, 123 girls, median age 4.5 years) recruited over 3 years, we found 2 boys (age 11 and 21 months) lacking serum immunoglobulinsand circulating B cells. Subsequent genetic analysis confirmed diagnosis of X-linked agammaglobulinemia. Despite their immunodeficiency, the pneumonia was uncomplicated in both patients and did not call for immunological evaluation. Howev

Název v anglickém jazyce

X-linked agammaglobulinemia in community-acquired pneumonia cases reveaeled by immunoglobulin level screening at hospital admission

Popis výsledku anglicky

In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare,some of the infections seen in immunodeficient patients are common. Defective antibody production represents the largest group among these disorders, with otitis, sinusitis and pneumonia as the most frequent initial manifestation. We performed a prospective study of humoralimmunity in children hospitalized due to community-acquired pneumonia in tertiary care hospital. Out of 254 patients (131 boys, 123 girls, median age 4.5 years) recruited over 3 years, we found 2 boys (age 11 and 21 months) lacking serum immunoglobulinsand circulating B cells. Subsequent genetic analysis confirmed diagnosis of X-linked agammaglobulinemia. Despite their immunodeficiency, the pneumonia was uncomplicated in both patients and did not call for immunological evaluation. Howev

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NS10398" target="_blank" >NS10398: Význam genu TACI a abnormalit lymfocytárních subpopulací v patogenezi selektivního deficitu IgA</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinische Pädiatrie

ISSN

0300-8630

e-ISSN

—

Svazek periodika

225

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

4

Strana od-do

339-342

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—