Adjuvant cardioprotection in cardiac surgery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F14%3A%230000303" target="_blank" >RIV/00209775:_____/14:#0000303 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.hindawi.com/journals/bmri/2014/808096/" target="_blank" >http://www.hindawi.com/journals/bmri/2014/808096/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/808096" target="_blank" >10.1155/2014/808096</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adjuvant cardioprotection in cardiac surgery

Popis výsledku v původním jazyce

Cardiac surgery patients are now more risky in terms of age, comorbidities, and the need for complex procedures. It brings about reperfusion injury, which leads to dysfunction and/or loss of part of the myocardium. These groups of patients have a higherincidence of postoperative complications and mortality. One way of augmenting intraoperative myocardial protection is the phenomenon of myocardial conditioning, elicited with brief nonlethal episodes of ischemia-reperfusion. In addition, drugs are beingtested that mimic ischaemic conditioning. Such cardioprotective techniques are mainly focused on reperfusion injury, a complex response of the organism to the restoration of coronary blood flow in ischaemic tissue, which can lead to cell death. Extensiveresearch over the last three decades has revealed the basic mechanisms of reperfusion injury and myocardial conditioning, suggesting its therapeutic potential. But despite the enormous efforts that have been expended in preclinical studi

Název v anglickém jazyce

Adjuvant cardioprotection in cardiac surgery

Popis výsledku anglicky

Cardiac surgery patients are now more risky in terms of age, comorbidities, and the need for complex procedures. It brings about reperfusion injury, which leads to dysfunction and/or loss of part of the myocardium. These groups of patients have a higherincidence of postoperative complications and mortality. One way of augmenting intraoperative myocardial protection is the phenomenon of myocardial conditioning, elicited with brief nonlethal episodes of ischemia-reperfusion. In addition, drugs are beingtested that mimic ischaemic conditioning. Such cardioprotective techniques are mainly focused on reperfusion injury, a complex response of the organism to the restoration of coronary blood flow in ischaemic tissue, which can lead to cell death. Extensiveresearch over the last three decades has revealed the basic mechanisms of reperfusion injury and myocardial conditioning, suggesting its therapeutic potential. But despite the enormous efforts that have been expended in preclinical studi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioMed Research International

ISSN

2314-6141

e-ISSN

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Svazek periodika

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Číslo periodika v rámci svazku

" ID 808096"

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

1-12

Kód UT WoS článku

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EID výsledku v databázi Scopus

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