Decreased exercise capacity and sleep-desordered breathing in patient with hyperthrophic cardiomyopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F15%3A%230000319" target="_blank" >RIV/00209775:_____/15:#0000319 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1378/chest.14-1498" target="_blank" >http://dx.doi.org/10.1378/chest.14-1498</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1378/chest.14-1498" target="_blank" >10.1378/chest.14-1498</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Decreased exercise capacity and sleep-desordered breathing in patient with hyperthrophic cardiomyopathy

Popis výsledku v původním jazyce

Mechanisms of decreased exercise capacity in patients with hypertrophic cardiomyopathy (HCM) are not well understood. Sleep-disordered breathing (SDB) is a highly prevalent but treatable disorder in patients with HCM. The role of comorbid SBD in the attenuated exercise capacity in HCM has not been previously. Overnight oximetry, cardiopulmonary exercise testing, and echocardiographic studies were performed in consecutive patients with HCM seen at the Mayo Clinic. SDB was considered present if the oxygen desaturation index (number of <= 4% desaturations/h) was >= 10. Peak oxygen consumption (V O2 peak) (the most reproducible and prognostic measure of cardiovascular fitness) was then correlated with the presence and severity of SBD. A total of 198 patients with HCM were studied (age 53+-16 years; 122 men), of whom 32% met the criteria for the SBD diagnosis. Patients with SBD had decreased V 02 peak compared with those without SBD (16 mL O2/kg/min vs 21 mL O2/kg/min, P < 0.001). SBD remained significantly associated with V O2peak after accounting for confounding clinical variables (P < 0.001) including age, sex, BMI, atrial fibrillation, and coronary artery disease. In patients with HCM, the presence of SBD is associated with decreased V O2 peak. SBD may represent an important and potentially modifiable contributor to impaired exercise tolerance in this unique population.

Název v anglickém jazyce

Decreased exercise capacity and sleep-desordered breathing in patient with hyperthrophic cardiomyopathy

Popis výsledku anglicky

Mechanisms of decreased exercise capacity in patients with hypertrophic cardiomyopathy (HCM) are not well understood. Sleep-disordered breathing (SDB) is a highly prevalent but treatable disorder in patients with HCM. The role of comorbid SBD in the attenuated exercise capacity in HCM has not been previously. Overnight oximetry, cardiopulmonary exercise testing, and echocardiographic studies were performed in consecutive patients with HCM seen at the Mayo Clinic. SDB was considered present if the oxygen desaturation index (number of <= 4% desaturations/h) was >= 10. Peak oxygen consumption (V O2 peak) (the most reproducible and prognostic measure of cardiovascular fitness) was then correlated with the presence and severity of SBD. A total of 198 patients with HCM were studied (age 53+-16 years; 122 men), of whom 32% met the criteria for the SBD diagnosis. Patients with SBD had decreased V 02 peak compared with those without SBD (16 mL O2/kg/min vs 21 mL O2/kg/min, P < 0.001). SBD remained significantly associated with V O2peak after accounting for confounding clinical variables (P < 0.001) including age, sex, BMI, atrial fibrillation, and coronary artery disease. In patients with HCM, the presence of SBD is associated with decreased V O2 peak. SBD may represent an important and potentially modifiable contributor to impaired exercise tolerance in this unique population.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chest

ISSN

0012-3692

e-ISSN

—

Svazek periodika

147

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1574-1581

Kód UT WoS článku

000355837900038

EID výsledku v databázi Scopus

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