Comparison of iron deficiency markers in patients with advanced heart failure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F25%3AN0000011" target="_blank" >RIV/00209775:_____/25:N0000011 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00392-025-02775-5" target="_blank" >https://link.springer.com/article/10.1007/s00392-025-02775-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00392-025-02775-5" target="_blank" >10.1007/s00392-025-02775-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of iron deficiency markers in patients with advanced heart failure

Popis výsledku v původním jazyce

Introduction: Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF). It is associated with reduced performance, frequent hospitalizations and low quality of life. There is an ongoing debate about the correct definition of ID in HF.Purpose: Refinement of the ID determination in patients with advanced HF. Evaluation of the association of iron metabolism parameters with other clinical characteristics.Patients and methods: One hundred-two patients with advanced HF were included, 48 in-patients, out-patients without LVAD and 25 of patients with LVAD implanted. In addition to conventional tests, we monitored iron metabolism parameters. The prevalence of ID was compared according to both the original and the updated ID definition. Correlations between individual iron markers and patients' functional capacity were measured.Results: The prevalence of ID in patients with advanced HF was 65%. There was no statistically significant difference in individual iron parameters between the groups. All parameters except ferritin correlated with NT-proBNP in the in-patient group. Serum iron correlated most strongly with NT-proBNP and CRP across all groups. The sTfR parameter correlated the most with right heart catheterization parameters, serum iron and TSAT were the most specific parameters related to functional status. Conclusion: Patients with more advanced HF and severe limitation of functional capacity had worse iron parameters. Ferritin seems to be the less specific marker of ID, while detecting ID using serum iron and TSAT seems to be reliable. The correlation of ferritin with functional status or haemodynamics was the weakest of all the parameters studied.

Název v anglickém jazyce

Comparison of iron deficiency markers in patients with advanced heart failure

Popis výsledku anglicky

Introduction: Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF). It is associated with reduced performance, frequent hospitalizations and low quality of life. There is an ongoing debate about the correct definition of ID in HF.Purpose: Refinement of the ID determination in patients with advanced HF. Evaluation of the association of iron metabolism parameters with other clinical characteristics.Patients and methods: One hundred-two patients with advanced HF were included, 48 in-patients, out-patients without LVAD and 25 of patients with LVAD implanted. In addition to conventional tests, we monitored iron metabolism parameters. The prevalence of ID was compared according to both the original and the updated ID definition. Correlations between individual iron markers and patients' functional capacity were measured.Results: The prevalence of ID in patients with advanced HF was 65%. There was no statistically significant difference in individual iron parameters between the groups. All parameters except ferritin correlated with NT-proBNP in the in-patient group. Serum iron correlated most strongly with NT-proBNP and CRP across all groups. The sTfR parameter correlated the most with right heart catheterization parameters, serum iron and TSAT were the most specific parameters related to functional status. Conclusion: Patients with more advanced HF and severe limitation of functional capacity had worse iron parameters. Ferritin seems to be the less specific marker of ID, while detecting ID using serum iron and TSAT seems to be reliable. The correlation of ferritin with functional status or haemodynamics was the weakest of all the parameters studied.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical research in cardiology

ISSN

1861-0684

e-ISSN

1861-0692

Svazek periodika

neuveden

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

001615695400001

EID výsledku v databázi Scopus

2-s2.0-105022299169