Cyclin-dependent kinase inhibitors induce a transcriptionally active form of p53 protein associated with nucleolar segregation

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cyclin-dependent kinase inhibitors induce a transcriptionally active form of p53 protein associated with nucleolar segregation

Popis výsledku v původním jazyce

The wild-type p53 protein is a critical participant in cellular responses to various cytotoxic stresses and its induction can result in either cell cycle arrest or in apoptotic cell death. Cyclin-dependent kinases (CDKs) play a key role in regulation ofcellular proliferation and apoptosis by phosphorylating many regulatory proteins including tumour suppressor p53. Recently, a new purine derivative olomoucine and roscovitine were described. They act as a potent inhibitors of the CDK1 and related kinases(CDK2, CDK5, erk1 and erk2). We have detected significant induction of wild-type but not mutant p53 protein after treatment the tumour cell lines with previously mentioned inhibitors.The induced p53 protein remains transcriptionally active.

Název v anglickém jazyce

Cyclin-dependent kinase inhibitors induce a transcriptionally active form of p53 protein associated with nucleolar segregation

Popis výsledku anglicky

The wild-type p53 protein is a critical participant in cellular responses to various cytotoxic stresses and its induction can result in either cell cycle arrest or in apoptotic cell death. Cyclin-dependent kinases (CDKs) play a key role in regulation ofcellular proliferation and apoptosis by phosphorylating many regulatory proteins including tumour suppressor p53. Recently, a new purine derivative olomoucine and roscovitine were described. They act as a potent inhibitors of the CDK1 and related kinases(CDK2, CDK5, erk1 and erk2). We have detected significant induction of wild-type but not mutant p53 protein after treatment the tumour cell lines with previously mentioned inhibitors.The induced p53 protein remains transcriptionally active.

Druh

D - Stať ve sborníku

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2000

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

10th international p53 workshop

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

neuv.

Místo vydání

Monterey

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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