Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F10%3A%230000258" target="_blank" >RIV/00209805:_____/10:#0000258 - isvavai.cz</a>

Výsledek na webu

<a href="http://cebp.aacrjournals.org/content/19/5/1341" target="_blank" >http://cebp.aacrjournals.org/content/19/5/1341</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-09-1019" target="_blank" >10.1158/1055-9965.EPI-09-1019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking?

Popis výsledku v původním jazyce

Background: Increased risk of renal cell carcinoma (RCC) with milk consumption has been reported from observational studies. Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the potential for using genetic variation in lactase persistence as a tool for the study of this relationship. Methods: Using a large, hospital-based case-control study, we used observational, phenotypic, and genetic data to determine whether the MCM6 -13910 C/T(rs4988235) variant may be used as a nonconfounded and unbiased marker for milk consumption. Results: Consumption of milk during adulthood was associated with increased risk of RCC [odds ratio (OR), 1.35; 95% confidence interval (95% CI), 1.03-1.76; P = 0.03]. Among controls, consumption of milk was associated with the lactase persistence genotype at rs4988235 (OR, 2.39; 95% CI, 1.81-3.15; P = 6.9 x 10-10); however, the same genotype was not associated with RCC (OR, 1.01; 95% CI, 0.83-1.22; P = 0.9).

Název v anglickém jazyce

Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking?

Popis výsledku anglicky

Background: Increased risk of renal cell carcinoma (RCC) with milk consumption has been reported from observational studies. Whether this represents a causal association or is a result of confounding or bias is unclear. We assessed the potential for using genetic variation in lactase persistence as a tool for the study of this relationship. Methods: Using a large, hospital-based case-control study, we used observational, phenotypic, and genetic data to determine whether the MCM6 -13910 C/T(rs4988235) variant may be used as a nonconfounded and unbiased marker for milk consumption. Results: Consumption of milk during adulthood was associated with increased risk of RCC [odds ratio (OR), 1.35; 95% confidence interval (95% CI), 1.03-1.76; P = 0.03]. Among controls, consumption of milk was associated with the lactase persistence genotype at rs4988235 (OR, 2.39; 95% CI, 1.81-3.15; P = 6.9 x 10-10); however, the same genotype was not associated with RCC (OR, 1.01; 95% CI, 0.83-1.22; P = 0.9).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer epidemiology biomarkers and prevention

ISSN

1055-9965

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1341-1348

Kód UT WoS článku

000278489800022

EID výsledku v databázi Scopus

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