The disulide bond formation and its relationship to bacterial pathogenicity of three important gram-negative bacteria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F11%3A%230000154" target="_blank" >RIV/00209805:_____/11:#0000154 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_3_4_WWW.pdf" target="_blank" >http://www.vojenskaskola.cz/school/ud/fmhs/research_development/Documents/MMSL_2011_3_4_WWW.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The disulide bond formation and its relationship to bacterial pathogenicity of three important gram-negative bacteria

Popis výsledku v původním jazyce

Disulfide bond formation is necessary for a correct folding and a proper function of many secreted proteins. We know that many of these proteins are involved in bacterial virulence and pathogenesis. The best known pathways of disulfide bond formation andisomerization belong to Escherichia coli (E. coli). This Gram-negative bacterium is usually used as a model organism. This review is aimed initially at introduction to E. coli oxido-reductase enzymatic system. The next part is interested in proteins resembling these from E. coli and their relation to virulence and pathogenesis. We have choosen three important Gramnegative pathogens, Neisseria meningitidis (N. meningitidis), Yersinia pestis (Y. pestis) and Francisella tularensis (F. tularensis), becauseof their high virulence, infectivity, ability to cause severe infections and absence of appropriate vaccines.

Název v anglickém jazyce

The disulide bond formation and its relationship to bacterial pathogenicity of three important gram-negative bacteria

Popis výsledku anglicky

Disulfide bond formation is necessary for a correct folding and a proper function of many secreted proteins. We know that many of these proteins are involved in bacterial virulence and pathogenesis. The best known pathways of disulfide bond formation andisomerization belong to Escherichia coli (E. coli). This Gram-negative bacterium is usually used as a model organism. This review is aimed initially at introduction to E. coli oxido-reductase enzymatic system. The next part is interested in proteins resembling these from E. coli and their relation to virulence and pathogenesis. We have choosen three important Gramnegative pathogens, Neisseria meningitidis (N. meningitidis), Yersinia pestis (Y. pestis) and Francisella tularensis (F. tularensis), becauseof their high virulence, infectivity, ability to cause severe infections and absence of appropriate vaccines.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Military medical science letters

ISSN

0372-7025

e-ISSN

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Svazek periodika

80

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

118-128

Kód UT WoS článku

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EID výsledku v databázi Scopus

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