MicroRNAs and their target gene networks in renal cell carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F11%3A%230000190" target="_blank" >RIV/00209805:_____/11:#0000190 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/11:00060083

Výsledek na webu

<a href="http://ac.els-cdn.com/S0006291X11000386/1-s2.0-S0006291X11000386-main.pdf?_tid=c85ef621e2e3ec6eb25b9022c5bfc00b&acdnat=1335544954_c2004911aa3d46b1b475f42d9a079440" target="_blank" >http://ac.els-cdn.com/S0006291X11000386/1-s2.0-S0006291X11000386-main.pdf?_tid=c85ef621e2e3ec6eb25b9022c5bfc00b&acdnat=1335544954_c2004911aa3d46b1b475f42d9a079440</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbrc.2011.01.019" target="_blank" >10.1016/j.bbrc.2011.01.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs and their target gene networks in renal cell carcinoma

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are non-protein-coding short single stranded RNAs in the size range 19-25 nucleotides that are associated with gene regulation at the transcriptional and translational level. Recent studies have proved that miRNAs play important rolesin a large number of biological processes, including cellular differentiation, proliferation, apoptosis. etc. Changes in their expression were found in a variety of human cancers, including renal cell carcinoma pathogenesis. Specific miRNA alterations were associated with key pathogenetic mechanisms of renal cell carcinoma like hypoxia or epithelial-mesenchymal transition. In this review, we summarize the current knowledge of miRNA functions in renal cell carcinoma with an emphasis on miRNAs potential to serve as a powerful biomarker of disease and a novel therapeutic target in oncology.

Název v anglickém jazyce

MicroRNAs and their target gene networks in renal cell carcinoma

Popis výsledku anglicky

MicroRNAs (miRNAs) are non-protein-coding short single stranded RNAs in the size range 19-25 nucleotides that are associated with gene regulation at the transcriptional and translational level. Recent studies have proved that miRNAs play important rolesin a large number of biological processes, including cellular differentiation, proliferation, apoptosis. etc. Changes in their expression were found in a variety of human cancers, including renal cell carcinoma pathogenesis. Specific miRNA alterations were associated with key pathogenetic mechanisms of renal cell carcinoma like hypoxia or epithelial-mesenchymal transition. In this review, we summarize the current knowledge of miRNA functions in renal cell carcinoma with an emphasis on miRNAs potential to serve as a powerful biomarker of disease and a novel therapeutic target in oncology.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemical and biophysical research communications

ISSN

0006-291X

e-ISSN

—

Svazek periodika

405

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

153-156

Kód UT WoS článku

000287627500001

EID výsledku v databázi Scopus

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