Concepts in MDM2 signaling: allosteric regulation and feedback loops
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000290" target="_blank" >RIV/00209805:_____/12:#0000290 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494372/pdf/10.1177_1947601912454140.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494372/pdf/10.1177_1947601912454140.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1947601912454140" target="_blank" >10.1177/1947601912454140</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Concepts in MDM2 signaling: allosteric regulation and feedback loops
Popis výsledku v původním jazyce
The function and regulation of MDM2 as a component of a p53-dependent negative feedback loop has formed a core paradigm in the p53 field. This concept, now 20 years old, has been solidified by fields of protein science, transgenic technology, and drug discovery in human cancer. However, it has been noted that a simple negative feedback loop between p53 and MDM2 lacks an intrinsic ?activating? step that counteracts this inhibition and permits oscillation of the feedback to occur as p53 is switched on andoff. More recent work has identified a solution to the missing piece of the picture that counters the negative feedback loop, which is MDM2 itself. Under conditions of genotoxic stress, MDM2 helps to activate p53 by increasing its rate of protein synthesis. This simple observation makes certain aspects of the p53 response more comprehensible such as why MDM2 is upregulated by p53 early on following DNA damage and how phosphorylation of MDM2 at the C-terminal Ser395 by ATM translates int
Název v anglickém jazyce
Concepts in MDM2 signaling: allosteric regulation and feedback loops
Popis výsledku anglicky
The function and regulation of MDM2 as a component of a p53-dependent negative feedback loop has formed a core paradigm in the p53 field. This concept, now 20 years old, has been solidified by fields of protein science, transgenic technology, and drug discovery in human cancer. However, it has been noted that a simple negative feedback loop between p53 and MDM2 lacks an intrinsic ?activating? step that counteracts this inhibition and permits oscillation of the feedback to occur as p53 is switched on andoff. More recent work has identified a solution to the missing piece of the picture that counters the negative feedback loop, which is MDM2 itself. Under conditions of genotoxic stress, MDM2 helps to activate p53 by increasing its rate of protein synthesis. This simple observation makes certain aspects of the p53 response more comprehensible such as why MDM2 is upregulated by p53 early on following DNA damage and how phosphorylation of MDM2 at the C-terminal Ser395 by ATM translates int
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Genes and cancer
ISSN
1947-6019
e-ISSN
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Svazek periodika
3
Číslo periodika v rámci svazku
3-4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
291-297
Kód UT WoS článku
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EID výsledku v databázi Scopus
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