Cancer as a metabolic disease and diabetes as a precancerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000299" target="_blank" >RIV/00209805:_____/12:#0000299 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4121.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4121.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cancer as a metabolic disease and diabetes as a precancerosis

Popis výsledku v původním jazyce

The prevailing aerobic glycolysis (so called Warburg effect) in cancer cells is according to current understanding the consequence of reprogramming of cellular metabolism during the process of malignant transformation. Metabolic regulation is inseparablecomponent of cell proliferation machinery and has a tight link with activities of oncogenes and suppressor genes. The purpose of metabolic reprogramming of cancer (but also normal intensively proliferating cells) is to incorporate greater fraction of glucose metabolites into newly synthesised macromolecules. Apart from that, aerobic glycolysis confers several other selective advantages to cancer cells. Epidemiological data indicate that type 2 diabetes mellitus is associated with increased ncidence ofseveral types of cancer and that cancer mortality can be influenced by ertain types of anti-diabetic treatment, however future research is needed to explain whether his relationship might be causal. Deeper knowledge about metabolic proper

Název v anglickém jazyce

Cancer as a metabolic disease and diabetes as a precancerosis

Popis výsledku anglicky

The prevailing aerobic glycolysis (so called Warburg effect) in cancer cells is according to current understanding the consequence of reprogramming of cellular metabolism during the process of malignant transformation. Metabolic regulation is inseparablecomponent of cell proliferation machinery and has a tight link with activities of oncogenes and suppressor genes. The purpose of metabolic reprogramming of cancer (but also normal intensively proliferating cells) is to incorporate greater fraction of glucose metabolites into newly synthesised macromolecules. Apart from that, aerobic glycolysis confers several other selective advantages to cancer cells. Epidemiological data indicate that type 2 diabetes mellitus is associated with increased ncidence ofseveral types of cancer and that cancer mortality can be influenced by ertain types of anti-diabetic treatment, however future research is needed to explain whether his relationship might be causal. Deeper knowledge about metabolic proper

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

supplementum 2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

"2S26"-"2S31"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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