The many roles of molecular chaperones and co-chaperones in tumour biology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000302" target="_blank" >RIV/00209805:_____/12:#0000302 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4127.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4127.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The many roles of molecular chaperones and co-chaperones in tumour biology

Popis výsledku v původním jazyce

Molecular chaperones (heat-shock proteins, Hsps) are proteins that maintain intracellular homeostasis through folding and stabilisation of the conformation of other proteins. Molecular chaperones are critical for survival of cells that undergo cellular stress due to their ability to guard the proteome against misfolded proteins and aggregation. In addition to their canonical role in basic cellular homeostasis and protection against external stress, several molecular chaperones play a fundamental role inmalignant cell transformation. The level of molecular chaperones is increased in many solid tumours and haematological malignancies. The increased activity of Hsps in cancer cells reflects the ability of chaperones to compensate for stress caused by hypoxia, increased protein turnover and the presence of numerous mutated and potentially unstable proteins. In addition, chaperones allow tumour cells to tolerate genetic alterations by stabilising tertiary structure of mutated unstable prot

Název v anglickém jazyce

The many roles of molecular chaperones and co-chaperones in tumour biology

Popis výsledku anglicky

Molecular chaperones (heat-shock proteins, Hsps) are proteins that maintain intracellular homeostasis through folding and stabilisation of the conformation of other proteins. Molecular chaperones are critical for survival of cells that undergo cellular stress due to their ability to guard the proteome against misfolded proteins and aggregation. In addition to their canonical role in basic cellular homeostasis and protection against external stress, several molecular chaperones play a fundamental role inmalignant cell transformation. The level of molecular chaperones is increased in many solid tumours and haematological malignancies. The increased activity of Hsps in cancer cells reflects the ability of chaperones to compensate for stress caused by hypoxia, increased protein turnover and the presence of numerous mutated and potentially unstable proteins. In addition, chaperones allow tumour cells to tolerate genetic alterations by stabilising tertiary structure of mutated unstable prot

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

supplementum 2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

"2S45"-"2S49"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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