Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000356" target="_blank" >RIV/00209805:_____/12:#0000356 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/ijc.27339/abstract;jsessionid=9AE9ABA5F412C1C8DE2F6962F06AB520.d01t01" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ijc.27339/abstract;jsessionid=9AE9ABA5F412C1C8DE2F6962F06AB520.d01t01</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijc.27339" target="_blank" >10.1002/ijc.27339</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies

Popis výsledku v původním jazyce

Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. This pooled analysis included 13,169 cases and 16,010 controls from Europe and Canada. Studies with population controls comprised 66.5% of the subjects. Adenocarcinoma (AdCa) was the most prevalent subtype in never smokers and in women. Squamous cell carcinoma (SqCC) predominated in male smokers. Age-adjusted odds ratios (ORs) were estimated with logistic regression. ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for AdCa. Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% confidence interval (CI): 74.8143.2) for SqCC, 111.3 (95% CI: 69.8177.5) for SCLC and 21.9 (95% CI: 16.629.

Název v anglickém jazyce

Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies

Popis výsledku anglicky

Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. This pooled analysis included 13,169 cases and 16,010 controls from Europe and Canada. Studies with population controls comprised 66.5% of the subjects. Adenocarcinoma (AdCa) was the most prevalent subtype in never smokers and in women. Squamous cell carcinoma (SqCC) predominated in male smokers. Age-adjusted odds ratios (ORs) were estimated with logistic regression. ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for AdCa. Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% confidence interval (CI): 74.8143.2) for SqCC, 111.3 (95% CI: 69.8177.5) for SCLC and 21.9 (95% CI: 16.629.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of cancer

ISSN

0020-7136

e-ISSN

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Svazek periodika

131

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1210-1219

Kód UT WoS článku

000305756900049

EID výsledku v databázi Scopus

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