MiR-34b is associated with clinical outcome in triple-negative breast cancer patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000375" target="_blank" >RIV/00209805:_____/12:#0000375 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.diagnosticpathology.org/content/7/1/31" target="_blank" >http://www.diagnosticpathology.org/content/7/1/31</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1746-1596-7-31" target="_blank" >10.1186/1746-1596-7-31</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MiR-34b is associated with clinical outcome in triple-negative breast cancer patients

Popis výsledku v původním jazyce

Background: Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) represents the major phenotype of basal-like molecular subtype of breast cancer, characterized by higherincidence in young women and a very poor prognosis. MicroRNAs (miRNAs) are small non-coding RNAs playing significant role in the pathogenesis of many cancers including breast cancer. Therefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients. Methods: Thirty-nine TNBC patients with available formalin-fixed paraffin-embedded (FFPE) tissues were enrolled in the study. MiR-34a, miR-34b, and miR-34c were analyzed using qRT-PCR and correlated to clinico-pathological features of TNBC patients. Results: Expression levels of miR-34b significantly correlate with disease free survival (DFS) (p = 0.0020, log-rank test) and overall survival (OS) (p = 0.0008, log-rank test) of TNBC patients

Název v anglickém jazyce

MiR-34b is associated with clinical outcome in triple-negative breast cancer patients

Popis výsledku anglicky

Background: Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) represents the major phenotype of basal-like molecular subtype of breast cancer, characterized by higherincidence in young women and a very poor prognosis. MicroRNAs (miRNAs) are small non-coding RNAs playing significant role in the pathogenesis of many cancers including breast cancer. Therefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients. Methods: Thirty-nine TNBC patients with available formalin-fixed paraffin-embedded (FFPE) tissues were enrolled in the study. MiR-34a, miR-34b, and miR-34c were analyzed using qRT-PCR and correlated to clinico-pathological features of TNBC patients. Results: Expression levels of miR-34b significantly correlate with disease free survival (DFS) (p = 0.0020, log-rank test) and overall survival (OS) (p = 0.0008, log-rank test) of TNBC patients

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10357" target="_blank" >NS10357: Epidemiologické, genetické a klinicko-patologické aspekty ?triple-negativního? (ER-?, PR, c-ErbB2 negativního) karcinomu prsu v populaci českých žen.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diagnostic pathology

ISSN

1746-1596

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

Mar 22

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000303885300001

EID výsledku v databázi Scopus

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