Hormones in breast carcinogenesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000460" target="_blank" >RIV/00209805:_____/13:#0000460 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.novapublishers.com/catalog/product_info.php?products_id=35752" target="_blank" >https://www.novapublishers.com/catalog/product_info.php?products_id=35752</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hormones in breast carcinogenesis

Popis výsledku v původním jazyce

Approximately one half of newly diagnosed female cancers are hormone-dependent, namely breast, ovarian and endometrial tumours. Female breast cancer incidence varies substantially worldwide with women in North America and Northern Europe at highest risk.On the basis of experimental, epidemiologic and clinical studies, ovarian hormones, estradiol and progesterone, influence normal breast cell growth and development and are therefore strongly implicated in the aetiology of human breast cancer. Particularmolecular mechanism of action of both hormones in carcinogenesis is being extensively studied. The originally described pathway includes the classical interaction of ligand-bound oestrogen receptor dimers with oestrogen-responsive elements in promoter region of target genes that promote growth of mammary epithelium. The main downstream mediators of oestrogen action include epidermal growth factor, transforming growth factors alpha and beta, platelet-derived growth factor, insulin?like g

Název v anglickém jazyce

Hormones in breast carcinogenesis

Popis výsledku anglicky

Approximately one half of newly diagnosed female cancers are hormone-dependent, namely breast, ovarian and endometrial tumours. Female breast cancer incidence varies substantially worldwide with women in North America and Northern Europe at highest risk.On the basis of experimental, epidemiologic and clinical studies, ovarian hormones, estradiol and progesterone, influence normal breast cell growth and development and are therefore strongly implicated in the aetiology of human breast cancer. Particularmolecular mechanism of action of both hormones in carcinogenesis is being extensively studied. The originally described pathway includes the classical interaction of ligand-bound oestrogen receptor dimers with oestrogen-responsive elements in promoter region of target genes that promote growth of mammary epithelium. The main downstream mediators of oestrogen action include epidermal growth factor, transforming growth factors alpha and beta, platelet-derived growth factor, insulin?like g

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Hormones and behavior

ISBN

978-1-62417-767-5

Počet stran výsledku

14

Strana od-do

121-134

Počet stran knihy

194

Název nakladatele

Nova Science Publishers

Místo vydání

New York

Kód UT WoS kapitoly

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