High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A%230000502" target="_blank" >RIV/00209805:_____/14:#0000502 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12074/abstract;jsessionid=4DB5A62D7481121DF746467FE256842E.f04t03" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jop.12074/abstract;jsessionid=4DB5A62D7481121DF746467FE256842E.f04t03</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jop.12074" target="_blank" >10.1111/jop.12074</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue

Popis výsledku v původním jazyce

p63 proteins are important in formation of the oral mucosa. Normal oral mucosa shows a balance between the six protein isoforms, whereas an imbalance between them is seen in squamous cell carcinomas (SCC). There is controversy over the clinical impact ofp63 in SCC, which may relate to different expression in different areas. In addition, p63 isoforms can act as p53-like molecules (TAp63) or can inhibit p53 functions (delNp63) and expression of these isoforms varies in different tumours. Here, we choseto concentrate on the most common intra-oral sub-site, SCC of the mobile tongue. Total p63, delNp63 and TAp63 were analysed separately using immunohistochemistry. The percentage of cells and intensity of expression of different isoforms of p63 was evaluated using a quick score method and correlated with clinical data in a group of 87 patients with tongue SCC. All tumours expressed p63 in at least 60% of the cells when using two different antibodies detecting all 6 isoforms. p63 expressio

Název v anglickém jazyce

High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue

Popis výsledku anglicky

p63 proteins are important in formation of the oral mucosa. Normal oral mucosa shows a balance between the six protein isoforms, whereas an imbalance between them is seen in squamous cell carcinomas (SCC). There is controversy over the clinical impact ofp63 in SCC, which may relate to different expression in different areas. In addition, p63 isoforms can act as p53-like molecules (TAp63) or can inhibit p53 functions (delNp63) and expression of these isoforms varies in different tumours. Here, we choseto concentrate on the most common intra-oral sub-site, SCC of the mobile tongue. Total p63, delNp63 and TAp63 were analysed separately using immunohistochemistry. The percentage of cells and intensity of expression of different isoforms of p63 was evaluated using a quick score method and correlated with clinical data in a group of 87 patients with tongue SCC. All tumours expressed p63 in at least 60% of the cells when using two different antibodies detecting all 6 isoforms. p63 expressio

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of oral pathology and medicine

ISSN

0904-2512

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

6

Strana od-do

14-19

Kód UT WoS článku

000329291500003

EID výsledku v databázi Scopus

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