Titanocene dihalides and ferrocenes bearing a pendant ?-D-Xylofuranos-5-yl or ?-D-Ribofuranos-5-yl Moiety. Synthesis, characterization, and cytotoxic activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A%230000516" target="_blank" >RIV/00209805:_____/14:#0000516 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.acs.org/doi/abs/10.1021/om500200r" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/om500200r</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/om500200r" target="_blank" >10.1021/om500200r</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Titanocene dihalides and ferrocenes bearing a pendant ?-D-Xylofuranos-5-yl or ?-D-Ribofuranos-5-yl Moiety. Synthesis, characterization, and cytotoxic activity

Popis výsledku v původním jazyce

Titanocene dichlorides of general formula [(?5-C5H5)(?5-C5H4R)TiCl2] (where R = 5-deoxy-1,2-di-O-isopropylidene-3-O-benzyl-?-D-xylofuranos-5-yl (Xylf) (8a); R = 5-deoxy-1,2-di-O-isopropylidene-3-O-benzyl-?-D-ribofuranos-5-yl (Ribf) (8b)) and [(?5-C5H4R)2TiCl2] (R = Xylf (9a); R = Ribf (9b)) were prepared by reaction of the corresponding lithium cyclopentadienides 7a,b with an equimolar amount of [(?5-C5H5)TiCl3] or a 0.5 mol amount of [TiCl4(THF)2]. Titanocene difluorides of the general formula [(?5-C5H4R1)(?5-C5H4R2)TiF2] (R1 = H and R2 = Ribf (10); R1 = R2 = Xylf (11a); R1 = R2 = Ribf (11b)) were obtained by fluorination of the corresponding titanocene dichlorides 8b and 9 with the fluorinating agent {2-(CH2NMe2)C6H4-?C,N}(n-Bu)2SnF in high yields. Alternatively, complexes 11 were prepared in a straightforward way by direct reaction of [TiF4(THF)2] with 2 equiv of the corresponding lithium cyclopentadienide 7a,b. Ferrocene complexes [(?5-C5H4R)2Fe] (R = Xylf (12a); R = Ribf (12b)) we

Název v anglickém jazyce

Titanocene dihalides and ferrocenes bearing a pendant ?-D-Xylofuranos-5-yl or ?-D-Ribofuranos-5-yl Moiety. Synthesis, characterization, and cytotoxic activity

Popis výsledku anglicky

Titanocene dichlorides of general formula [(?5-C5H5)(?5-C5H4R)TiCl2] (where R = 5-deoxy-1,2-di-O-isopropylidene-3-O-benzyl-?-D-xylofuranos-5-yl (Xylf) (8a); R = 5-deoxy-1,2-di-O-isopropylidene-3-O-benzyl-?-D-ribofuranos-5-yl (Ribf) (8b)) and [(?5-C5H4R)2TiCl2] (R = Xylf (9a); R = Ribf (9b)) were prepared by reaction of the corresponding lithium cyclopentadienides 7a,b with an equimolar amount of [(?5-C5H5)TiCl3] or a 0.5 mol amount of [TiCl4(THF)2]. Titanocene difluorides of the general formula [(?5-C5H4R1)(?5-C5H4R2)TiF2] (R1 = H and R2 = Ribf (10); R1 = R2 = Xylf (11a); R1 = R2 = Ribf (11b)) were obtained by fluorination of the corresponding titanocene dichlorides 8b and 9 with the fluorinating agent {2-(CH2NMe2)C6H4-?C,N}(n-Bu)2SnF in high yields. Alternatively, complexes 11 were prepared in a straightforward way by direct reaction of [TiF4(THF)2] with 2 equiv of the corresponding lithium cyclopentadienide 7a,b. Ferrocene complexes [(?5-C5H4R)2Fe] (R = Xylf (12a); R = Ribf (12b)) we

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and molecular pathology

ISSN

0014-4800

e-ISSN

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Svazek periodika

96

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

375-381

Kód UT WoS článku

000337212600016

EID výsledku v databázi Scopus

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