The presence of B-cell activating factor (BAFF) in umbilicalcord blood in both healthy and pre-eclamptic pregnanciesand in human breast milk

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000624" target="_blank" >RIV/00209805:_____/15:#0000624 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/15:00082636 RIV/65269705:_____/15:00063666

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jri.2014.12.003" target="_blank" >http://dx.doi.org/10.1016/j.jri.2014.12.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jri.2014.12.003" target="_blank" >10.1016/j.jri.2014.12.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The presence of B-cell activating factor (BAFF) in umbilicalcord blood in both healthy and pre-eclamptic pregnanciesand in human breast milk

Popis výsledku v původním jazyce

B-cell activating factor (BAFF) is an important immune regulator that was recently reported to be secreted by placenta. The aim of the study was to investigate the presence of BAFF in umbilical cord blood, maternal serum, and breast milk in normal and in pre-eclamptic pregnancies. Pairs of maternal serum/umbilical cord blood were obtained from 12 pre-eclamptic and 34 physiological pregnancies. Another cohort of 10 healthy lactating women was established that was followed up for 6 months following delivery to investigate BAFF levels in breast milk. BAFF levels in maternal peripheral blood were significantly higher in physiological pregnancies than in pre-eclamptic pregnancies (p < 0.03). Furthermore, we observed a consistent presence of BAFF in breast milk during the 6-month post-partum period of breastfeeding. In this study, we demonstrate that BAFF levels are significantly lower in maternal peripheral blood in pre-eclamptic pregnancies. We also report the con-sistent presence of BAFF in breast milk in healthy women. More research into the role of BAFF in pregnancy, and during breastfeeding, is imperative.

Název v anglickém jazyce

The presence of B-cell activating factor (BAFF) in umbilicalcord blood in both healthy and pre-eclamptic pregnanciesand in human breast milk

Popis výsledku anglicky

B-cell activating factor (BAFF) is an important immune regulator that was recently reported to be secreted by placenta. The aim of the study was to investigate the presence of BAFF in umbilical cord blood, maternal serum, and breast milk in normal and in pre-eclamptic pregnancies. Pairs of maternal serum/umbilical cord blood were obtained from 12 pre-eclamptic and 34 physiological pregnancies. Another cohort of 10 healthy lactating women was established that was followed up for 6 months following delivery to investigate BAFF levels in breast milk. BAFF levels in maternal peripheral blood were significantly higher in physiological pregnancies than in pre-eclamptic pregnancies (p < 0.03). Furthermore, we observed a consistent presence of BAFF in breast milk during the 6-month post-partum period of breastfeeding. In this study, we demonstrate that BAFF levels are significantly lower in maternal peripheral blood in pre-eclamptic pregnancies. We also report the con-sistent presence of BAFF in breast milk in healthy women. More research into the role of BAFF in pregnancy, and during breastfeeding, is imperative.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of reproductive immunology

ISSN

0165-0378

e-ISSN

—

Svazek periodika

109

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

89-93

Kód UT WoS článku

000355364600013

EID výsledku v databázi Scopus

2-s2.0-84928769662