Pioneer translation products as an alternative source for MHC-I antigenic peptides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000656" target="_blank" >RIV/00209805:_____/15:#0000656 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.molimm.2015.04.019" target="_blank" >http://dx.doi.org/10.1016/j.molimm.2015.04.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molimm.2015.04.019" target="_blank" >10.1016/j.molimm.2015.04.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pioneer translation products as an alternative source for MHC-I antigenic peptides

Popis výsledku v původním jazyce

The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsensemediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensurethat the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. Thecharacterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies

Název v anglickém jazyce

Pioneer translation products as an alternative source for MHC-I antigenic peptides

Popis výsledku anglicky

The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsensemediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensurethat the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. Thecharacterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular immunology

ISSN

0161-5890

e-ISSN

—

Svazek periodika

68

Číslo periodika v rámci svazku

2, part A

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

68-71

Kód UT WoS článku

000366767700002

EID výsledku v databázi Scopus

2-s2.0-84955632443