Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F16%3AN0000025" target="_blank" >RIV/00209805:_____/16:N0000025 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00093816

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786871/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786871/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ncomms10933" target="_blank" >10.1038/ncomms10933</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Popis výsledku v původním jazyce

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55×10-11), 6p25.2 (rs73718779, SERPINB6, P=1.97×10-8) and 3q28 (rs9815073, LPP, P=3.62×10-8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00×10-11) in the combined analysis. We find suggestive evidence (P˂ 5×10-7) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19×10-8) and 3p22.2 (rs1274963, CSRNP1, P=2.12×10-7). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Název v anglickém jazyce

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Popis výsledku anglicky

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55×10-11), 6p25.2 (rs73718779, SERPINB6, P=1.97×10-8) and 3q28 (rs9815073, LPP, P=3.62×10-8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00×10-11) in the combined analysis. We find suggestive evidence (P˂ 5×10-7) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19×10-8) and 3p22.2 (rs1274963, CSRNP1, P=2.12×10-7). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regionální centrum aplikované molekulární onkologie (RECAMO)</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

2041-1723

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

9 March 2016

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

10933

Kód UT WoS článku

000371729200001

EID výsledku v databázi Scopus

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