Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078004" target="_blank" >RIV/00209805:_____/18:00078004 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00104694 RIV/00159816:_____/18:00068961

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043880/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043880/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/raon-2018-0023" target="_blank" >10.2478/raon-2018-0023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?

Popis výsledku v původním jazyce

Background. The current standard of care of glioblastoma, the most common primary brain tumor in adults, has remained unchanged for over a decade. Nevertheless, some improvements in patient outcomes have occurred as a consequence of modern surgery, improved radiotherapy and up-to-date management of toxicity. Patients from control arms (receiving standard concurrent chemoradiotherapy and adjuvant chemotherapy with temozolomide) of recent clinical trials achieve better outcomes compared to the median survival of 14.6 months reported in Stupp&apos;s landmark clinical trial in 2005. The approach to radiotherapy that emerged from Stupp&apos;s trial, which continues to be a basis for the current standard of care, is no longer applicable and there is a need to develop updated guidelines for radiotherapy within the daily clinical practice that address or at least acknowledge existing controversies in the planning of radiotherapy. The goal of this review is to provoke critical thinking about potentially controversial aspects in the radiotherapy of glioblastoma, including among others the issue of target definitions, simultaneously integrated boost technique, and hippocampal sparing. Conclusions. In conjunction with new treatment approaches such as tumor-treating fields (TTF) and immunotherapy, the role of adjuvant radiotherapy will be further defined. The personalized approach in daily radiotherapy practice is enabled with modern radiotherapy systems.

Název v anglickém jazyce

Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?

Popis výsledku anglicky

Background. The current standard of care of glioblastoma, the most common primary brain tumor in adults, has remained unchanged for over a decade. Nevertheless, some improvements in patient outcomes have occurred as a consequence of modern surgery, improved radiotherapy and up-to-date management of toxicity. Patients from control arms (receiving standard concurrent chemoradiotherapy and adjuvant chemotherapy with temozolomide) of recent clinical trials achieve better outcomes compared to the median survival of 14.6 months reported in Stupp&apos;s landmark clinical trial in 2005. The approach to radiotherapy that emerged from Stupp&apos;s trial, which continues to be a basis for the current standard of care, is no longer applicable and there is a need to develop updated guidelines for radiotherapy within the daily clinical practice that address or at least acknowledge existing controversies in the planning of radiotherapy. The goal of this review is to provoke critical thinking about potentially controversial aspects in the radiotherapy of glioblastoma, including among others the issue of target definitions, simultaneously integrated boost technique, and hippocampal sparing. Conclusions. In conjunction with new treatment approaches such as tumor-treating fields (TTF) and immunotherapy, the role of adjuvant radiotherapy will be further defined. The personalized approach in daily radiotherapy practice is enabled with modern radiotherapy systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiology and oncology

ISSN

1318-2099

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SI - Slovinská republika

Počet stran výsledku

8

Strana od-do

121-128

Kód UT WoS článku

000433103400001

EID výsledku v databázi Scopus

2-s2.0-85048757842