Acupuncture in the Treatment of Acute Toxicity During and After Head and Neck Cancer Radiotherapy: Interim Analysis of Randomized Prospective Open-Label Trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078409" target="_blank" >RIV/00209805:_____/20:00078409 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/20:00118033

Výsledek na webu

<a href="https://biomed.papers.upol.cz/artkey/bio-202004-0014_acupuncture-in-the-treatment-of-acute-toxicity-during-and-after-head-and-neck-cancer-radiotherapy-interim-anal.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202004-0014_acupuncture-in-the-treatment-of-acute-toxicity-during-and-after-head-and-neck-cancer-radiotherapy-interim-anal.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2020.021" target="_blank" >10.5507/bp.2020.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acupuncture in the Treatment of Acute Toxicity During and After Head and Neck Cancer Radiotherapy: Interim Analysis of Randomized Prospective Open-Label Trial

Popis výsledku v původním jazyce

Aims: The aim of this investigator-initiated prospective randomized open-label single institutional trial is to evaluate the role of acupuncture in the treatment of acute skin and mucosal toxicity, xerostomia, and perception of taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. This paper reports pilot data of the first 30 enrolled patients. Methods: Patients were randomized to undergo standard of care radiotherapy +- chemotherapy and support care defined by our institutional standard operating procedures alone or in the combination with acupuncture which was initiated with the first signs of any toxicity. Results: Fifteen patients were enrolled in both arms and all finished the treatment as planned.The median pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 points on a 10-item Likert scale; P=0.035) as well as duration of acute pain (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had significantly shorter duration of acute skin (median 44 days vs. 109 days; P&lt;0.001) and mucosal toxicity (median 34 days vs. 109 days; P&lt;0.001) with no difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant difference was found for other toxicity domains, with the exception of salivation toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 1.7; P=0.048). Conclusion: In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers. Trial registration: Clinicaltrials.gov - NCT03751566.

Název v anglickém jazyce

Acupuncture in the Treatment of Acute Toxicity During and After Head and Neck Cancer Radiotherapy: Interim Analysis of Randomized Prospective Open-Label Trial

Popis výsledku anglicky

Aims: The aim of this investigator-initiated prospective randomized open-label single institutional trial is to evaluate the role of acupuncture in the treatment of acute skin and mucosal toxicity, xerostomia, and perception of taste, pain, and nausea related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. This paper reports pilot data of the first 30 enrolled patients. Methods: Patients were randomized to undergo standard of care radiotherapy +- chemotherapy and support care defined by our institutional standard operating procedures alone or in the combination with acupuncture which was initiated with the first signs of any toxicity. Results: Fifteen patients were enrolled in both arms and all finished the treatment as planned.The median pain was significantly lower in the acupuncture arm (median 1.6 points vs. 2.5 points on a 10-item Likert scale; P=0.035) as well as duration of acute pain (median 31 days vs. 54 days; P=0.031). Patients with acupuncture had significantly shorter duration of acute skin (median 44 days vs. 109 days; P&lt;0.001) and mucosal toxicity (median 34 days vs. 109 days; P&lt;0.001) with no difference in grading of toxicity (median grade 1.6 vs. 1.5; P=0.701 and median grade 1.4 vs. 1.6; P=0.204 for skin and mucosa, respectively). No significant difference was found for other toxicity domains, with the exception of salivation toxicity which was significantly lower in acupuncture arm (median grade 1.3 vs. 1.7; P=0.048). Conclusion: In this interim analysis, acupuncture leads to lower pain andfaster disappearance of skin and mucosal toxicity after (chemo)radiotherapy of head and neck cancer. Description and validation of acupuncture using scientific approaches will further enhance acceptance of this method by both patients and health care providers. Trial registration: Clinicaltrials.gov - NCT03751566.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

164

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

454-460

Kód UT WoS článku

000604951200014

EID výsledku v databázi Scopus

2-s2.0-85097741416