Diagnostic Relevance of 18F-FDG PET/CT in Newly Diagnosed Patients With Monoclonal Gammopathy of Undetermined Significance (MGUS): Single-center Experience

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078414" target="_blank" >RIV/00209805:_____/20:00078414 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/20:00116304 RIV/65269705:_____/20:00072929

Výsledek na webu

<a href="http://www.elis.sk/index.php?page=shop.browse&category_id=160&option=com_virtuemart&Itemid=1" target="_blank" >http://www.elis.sk/index.php?page=shop.browse&category_id=160&option=com_virtuemart&Itemid=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2020_191104n1137" target="_blank" >10.4149/neo_2020_191104n1137</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic Relevance of 18F-FDG PET/CT in Newly Diagnosed Patients With Monoclonal Gammopathy of Undetermined Significance (MGUS): Single-center Experience

Popis výsledku v původním jazyce

Monoclonal gammopathy of undetermined significance (MGUS) is a known precursor of more serious cancers, such as multiple myeloma (MM), Waldenström macroglobulinemia (MW) and other lymphoproliferative disorders. Using 18F-FDG PET/CT, we aimed to evaluate its benefit in early detection of various accompanying disorders and illnesses in MGUS patients. We prospectively analyzed the diagnostic relevance of 18F-FDG PET/CT in 390 newly diagnosed MGUS patients. On 18F-FDG PET/CT scans, the presence of focal or diffuse areas of detectable increased tracer uptake was recorded in 37 (9.5%) MGUS patients. The most frequent pathology was lymphadenopathy (3.8%), followed by thyroid diseases (2.1%), rheumatologic diseases (1.8%), and other solid malignancies (1.5%). These results have major implications for confirmed associations of MGUS with numerous malignant and non-malignant disorders. We believe that 18F-FDG PET/CT imaging in newly diagnosed MGUS patients may be useful in early detection of other serious pathologies, not only in predicting progression of MGUS to active MM, and should be strongly recommended if available.

Název v anglickém jazyce

Diagnostic Relevance of 18F-FDG PET/CT in Newly Diagnosed Patients With Monoclonal Gammopathy of Undetermined Significance (MGUS): Single-center Experience

Popis výsledku anglicky

Monoclonal gammopathy of undetermined significance (MGUS) is a known precursor of more serious cancers, such as multiple myeloma (MM), Waldenström macroglobulinemia (MW) and other lymphoproliferative disorders. Using 18F-FDG PET/CT, we aimed to evaluate its benefit in early detection of various accompanying disorders and illnesses in MGUS patients. We prospectively analyzed the diagnostic relevance of 18F-FDG PET/CT in 390 newly diagnosed MGUS patients. On 18F-FDG PET/CT scans, the presence of focal or diffuse areas of detectable increased tracer uptake was recorded in 37 (9.5%) MGUS patients. The most frequent pathology was lymphadenopathy (3.8%), followed by thyroid diseases (2.1%), rheumatologic diseases (1.8%), and other solid malignancies (1.5%). These results have major implications for confirmed associations of MGUS with numerous malignant and non-malignant disorders. We believe that 18F-FDG PET/CT imaging in newly diagnosed MGUS patients may be useful in early detection of other serious pathologies, not only in predicting progression of MGUS to active MM, and should be strongly recommended if available.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

67

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

939-945

Kód UT WoS článku

000557901000025

EID výsledku v databázi Scopus

2-s2.0-85088882467