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Hospitals and pharmacies as sources of contamination by cytostatic pharmaceuticals: Long term monitoring in the Czech Republic

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078586" target="_blank" >RIV/00209805:_____/20:00078586 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216224:14310/20:00116151

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1007/978-3-030-21048-9_3" target="_blank" >http://dx.doi.org/10.1007/978-3-030-21048-9_3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/978-3-030-21048-9_3" target="_blank" >10.1007/978-3-030-21048-9_3</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Hospitals and pharmacies as sources of contamination by cytostatic pharmaceuticals: Long term monitoring in the Czech Republic

  • Popis výsledku v původním jazyce

    Two of the important contamination sources by antineoplastic drugs (AD) are hospitals and pharmacies. Unwanted releases have been documented during all steps of the preparation and administration of these hazardous drugs to patients leading to contamination of both working places and outside environment (transfer by aerosols, contaminated materials, or water after cleaning). Here we present results of a long-term project from 21 hospitals in the Czech Republic (971 samples; 2008-2016) investigating the contamination by major AD-5-fluorouracil (FU), cyclophosphamide (CP) and platinum drugs (total Pt as a sum of broadly used Pt-based drugs cisplatin, oxaliplatin, and carboplatin). In general, lower median levels of contamination have been found in pharmacies, which could be attributed to personnel education and higher safety working standards. On the other hand, surface contamination in other hospital areas exceeded the suggested threshold guidance values (TGVs) in up to 40% of samples depending on the monitored drug (TGVs being 67, 12, and 38 pg per square cm for CP, Pt, and FU, respectively). The highest values, maxima exceeding 29,000 and 49,000 pg per square cm for CP and FU, respectively, have repeatedly been found in outpatient clinics. The monitoring and discussions with responsible managers promoted the implementation of proper procedures and technologies that resulted in an overall decrease of the contamination during the monitored period.

  • Název v anglickém jazyce

    Hospitals and pharmacies as sources of contamination by cytostatic pharmaceuticals: Long term monitoring in the Czech Republic

  • Popis výsledku anglicky

    Two of the important contamination sources by antineoplastic drugs (AD) are hospitals and pharmacies. Unwanted releases have been documented during all steps of the preparation and administration of these hazardous drugs to patients leading to contamination of both working places and outside environment (transfer by aerosols, contaminated materials, or water after cleaning). Here we present results of a long-term project from 21 hospitals in the Czech Republic (971 samples; 2008-2016) investigating the contamination by major AD-5-fluorouracil (FU), cyclophosphamide (CP) and platinum drugs (total Pt as a sum of broadly used Pt-based drugs cisplatin, oxaliplatin, and carboplatin). In general, lower median levels of contamination have been found in pharmacies, which could be attributed to personnel education and higher safety working standards. On the other hand, surface contamination in other hospital areas exceeded the suggested threshold guidance values (TGVs) in up to 40% of samples depending on the monitored drug (TGVs being 67, 12, and 38 pg per square cm for CP, Pt, and FU, respectively). The highest values, maxima exceeding 29,000 and 49,000 pg per square cm for CP and FU, respectively, have repeatedly been found in outpatient clinics. The monitoring and discussions with responsible managers promoted the implementation of proper procedures and technologies that resulted in an overall decrease of the contamination during the monitored period.

Klasifikace

  • Druh

    C - Kapitola v odborné knize

  • CEP obor

  • OECD FORD obor

    30104 - Pharmacology and pharmacy

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název knihy nebo sborníku

    Fate and Effects of Anticancer Drugs in the Environment

  • ISBN

    978-3-030-21047-2

  • Počet stran výsledku

    14

  • Strana od-do

    1-14

  • Počet stran knihy

    469

  • Název nakladatele

    Springer

  • Místo vydání

    Switzerland

  • Kód UT WoS kapitoly