In search of the cell biology for self- versus non-self- recognition
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F23%3A00079308" target="_blank" >RIV/00209805:_____/23:00079308 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0952791523000535?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0952791523000535?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.coi.2023.102334" target="_blank" >10.1016/j.coi.2023.102334</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
In search of the cell biology for self- versus non-self- recognition
Popis výsledku v původním jazyce
Several of today's cancer treatments are based on the immune system's capacity to detect and destroy cells expressing neoantigens on major histocompatibility class-I molecules (MHC-I). Despite this, we still do not know the cell biology behind how antigenic peptide substrates (APSs) for the MHC-I pathway are produced. Indeed, there are few research fields with so many divergent views as the one concerning the source of APSs. This is quite remarkable considering their fundamental role in the immune systems' capacity to detect and destroy virus-infected or transformed cells. A better understanding of the processes generating APSs and how these are regulated will shed light on the evolution of self-recognition and provide new targets for therapeutic intervention. We discuss the search for the elusive source of MHC-I peptides and highlight the cell biology that is still missing to explain how they are synthesised and where they come from.
Název v anglickém jazyce
In search of the cell biology for self- versus non-self- recognition
Popis výsledku anglicky
Several of today's cancer treatments are based on the immune system's capacity to detect and destroy cells expressing neoantigens on major histocompatibility class-I molecules (MHC-I). Despite this, we still do not know the cell biology behind how antigenic peptide substrates (APSs) for the MHC-I pathway are produced. Indeed, there are few research fields with so many divergent views as the one concerning the source of APSs. This is quite remarkable considering their fundamental role in the immune systems' capacity to detect and destroy virus-infected or transformed cells. A better understanding of the processes generating APSs and how these are regulated will shed light on the evolution of self-recognition and provide new targets for therapeutic intervention. We discuss the search for the elusive source of MHC-I peptides and highlight the cell biology that is still missing to explain how they are synthesised and where they come from.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/GA23-06884S" target="_blank" >GA23-06884S: Charakterizace ribozomu překládajícího pre-spliced mRNA pro syntézu antigenních peptidových substrátů pro dráhu MHC-I</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current opinion in immunology
ISSN
0952-7915
e-ISSN
1879-0372
Svazek periodika
83
Číslo periodika v rámci svazku
August 2023
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
102334
Kód UT WoS článku
001009349500001
EID výsledku v databázi Scopus
2-s2.0-85159605217