Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079452" target="_blank" >RIV/00209805:_____/24:00079452 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/24:10482056

Výsledek na webu

<a href="https://www.atsjournals.org/doi/10.1164/rccm.202306-0942OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed" target="_blank" >https://www.atsjournals.org/doi/10.1164/rccm.202306-0942OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1164/rccm.202306-0942OC" target="_blank" >10.1164/rccm.202306-0942OC</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Popis výsledku v původním jazyce

RATIONALE: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. OBJECTIVES: We aimed to examine the relationship between occupational benzene exposure and lung cancer. METHODS: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. MEASUREMENTS AND MAIN RESULTS: Analyses included 28048 subjects (12329 cases, 15719 controls). Lung cancer odds ratios ranged from 1.12 (95% CI: 1.03-1.22) to 1.32 (95% CI: 1.18-1.48) (P(trend)=0.002) for groups with the lowest and highest cumulative occupational exposure, respectively, compared to unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (P(trend)&lt;0.001) and decreasing trend with longer time since last exposure (P(trend)=0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. CONCLUSION: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including non-smokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.

Název v anglickém jazyce

Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Popis výsledku anglicky

RATIONALE: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. OBJECTIVES: We aimed to examine the relationship between occupational benzene exposure and lung cancer. METHODS: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. MEASUREMENTS AND MAIN RESULTS: Analyses included 28048 subjects (12329 cases, 15719 controls). Lung cancer odds ratios ranged from 1.12 (95% CI: 1.03-1.22) to 1.32 (95% CI: 1.18-1.48) (P(trend)=0.002) for groups with the lowest and highest cumulative occupational exposure, respectively, compared to unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (P(trend)&lt;0.001) and decreasing trend with longer time since last exposure (P(trend)=0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. CONCLUSION: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including non-smokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of respiratory and critical care medicine

ISSN

1073-449X

e-ISSN

1535-4970

Svazek periodika

209

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

185-196

Kód UT WoS článku

001183674600012

EID výsledku v databázi Scopus

2-s2.0-85182501504