Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079645" target="_blank" >RIV/00209805:_____/24:00079645 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00136172 RIV/00216208:11110/24:10475832 RIV/65269705:_____/24:00079460

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836005/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836005/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40364-024-00563-3" target="_blank" >10.1186/s40364-024-00563-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

Popis výsledku v původním jazyce

Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.

Název v anglickém jazyce

Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

Popis výsledku anglicky

Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomarker Research

ISSN

2050-7771

e-ISSN

2050-7771

Svazek periodika

12

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

24

Strana od-do

15

Kód UT WoS článku

001155019100001

EID výsledku v databázi Scopus

2-s2.0-85183690921