Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079763" target="_blank" >RIV/00209805:_____/24:00079763 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00136239 RIV/65269705:_____/24:00080339

Výsledek na webu

<a href="https://journals.viamedica.pl/rpor/article/view/99362" target="_blank" >https://journals.viamedica.pl/rpor/article/view/99362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/rpor.99362" target="_blank" >10.5603/rpor.99362</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

Popis výsledku v původním jazyce

Background: The aim of this retrospective study is to analyze a consecutive cohort of brain metastasis (BM) patients treatedoff clinical trials through combination of surgery and radiotherapy over the last 15 years in a tertiary neurooncology center.Materials and methods: All BM patients operated between 2007-2019 received adjuvant linac-based radiotherapy categorizedto whole brain radiotherapy (WBRT) and tumor bed stereotactic radiotherapy. Survival outcomes and local control was analyzed.Results: In total, 118 patients were enrolled, those with stereotactic radiotherapy (41%) had better baseline characteristics mirrored in longer overall survival (OS) [18 vs. 7.1 months, p &lt; 0.001; hazard ratio (HR) 0.47, p = 0.004] with median follow-up of 58 months. Cumulative incidence for local, distant, and extracranial control was not significantly different betweengroups, with 12-month cumulative control of 22% vs. 18%, 44% vs. 29%, and 35% vs. 32% for stereotactic and WBRT group,respectively. WBRT was an independent factor for better distal brain control.Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidencefor local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule withoutcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.

Název v anglickém jazyce

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

Popis výsledku anglicky

Background: The aim of this retrospective study is to analyze a consecutive cohort of brain metastasis (BM) patients treatedoff clinical trials through combination of surgery and radiotherapy over the last 15 years in a tertiary neurooncology center.Materials and methods: All BM patients operated between 2007-2019 received adjuvant linac-based radiotherapy categorizedto whole brain radiotherapy (WBRT) and tumor bed stereotactic radiotherapy. Survival outcomes and local control was analyzed.Results: In total, 118 patients were enrolled, those with stereotactic radiotherapy (41%) had better baseline characteristics mirrored in longer overall survival (OS) [18 vs. 7.1 months, p &lt; 0.001; hazard ratio (HR) 0.47, p = 0.004] with median follow-up of 58 months. Cumulative incidence for local, distant, and extracranial control was not significantly different betweengroups, with 12-month cumulative control of 22% vs. 18%, 44% vs. 29%, and 35% vs. 32% for stereotactic and WBRT group,respectively. WBRT was an independent factor for better distal brain control.Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidencefor local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule withoutcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Reports of Practical Oncology and Radiotherapy

ISSN

1507-1367

e-ISSN

2083-4640

Svazek periodika

29

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

12

Strana od-do

30-41

Kód UT WoS článku

001293214500001

EID výsledku v databázi Scopus

2-s2.0-85188780134