Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079822" target="_blank" >RIV/00209805:_____/24:00079822 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00136799 RIV/65269705:_____/24:00080213

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2352340924005572" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352340924005572</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dib.2024.110590" target="_blank" >10.1016/j.dib.2024.110590</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors

Popis výsledku v původním jazyce

Alterations in DNA methylation profiles belong to important mechanisms in cancer development, and their assessment can be utilized for rapid and precise diagnostics. Therefore, establishing datasets of methylation profiles can improve and deepen our understanding of the role of epigenetic changes in cancer development as well as improve our diagnostic capabilities. In this dataset, we generated NGS data for 189 samples of pediatric CNS, soft tissue, and bone tumors. The sequencing libraries were prepared using methyl capture bisulfite sequencing, an effective compromise between whole-genome bisulfite sequencing and array-based methods with a more limited scope of target regions. The larger part of the cohort was processed with the Agilent SureSelectXT Human Methyl-Seq kit (149 samples) and the rest with the Illumina TruSeq Methyl Capture EPIC Library Prep Kit (40 samples). The data presented in this article may help other researchers further elucidate the importance of methylation in diagnosing pediatric CNS tumors, soft tissue, and bone tumors.

Název v anglickém jazyce

Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors

Popis výsledku anglicky

Alterations in DNA methylation profiles belong to important mechanisms in cancer development, and their assessment can be utilized for rapid and precise diagnostics. Therefore, establishing datasets of methylation profiles can improve and deepen our understanding of the role of epigenetic changes in cancer development as well as improve our diagnostic capabilities. In this dataset, we generated NGS data for 189 samples of pediatric CNS, soft tissue, and bone tumors. The sequencing libraries were prepared using methyl capture bisulfite sequencing, an effective compromise between whole-genome bisulfite sequencing and array-based methods with a more limited scope of target regions. The larger part of the cohort was processed with the Agilent SureSelectXT Human Methyl-Seq kit (149 samples) and the rest with the Illumina TruSeq Methyl Capture EPIC Library Prep Kit (40 samples). The data presented in this article may help other researchers further elucidate the importance of methylation in diagnosing pediatric CNS tumors, soft tissue, and bone tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Data in Brief

ISSN

2352-3409

e-ISSN

—

Svazek periodika

55

Číslo periodika v rámci svazku

August 2024

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

110590

Kód UT WoS článku

001253782800001

EID výsledku v databázi Scopus

2-s2.0-85195815751