Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080191" target="_blank" >RIV/00209805:_____/25:00080191 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/25:00082324

Výsledek na webu

<a href="https://journals.lww.com/pancreasjournal/fulltext/2025/01000/ex_vivo_3d_cellular_models_of_pancreatic_ductal.9.aspx" target="_blank" >https://journals.lww.com/pancreasjournal/fulltext/2025/01000/ex_vivo_3d_cellular_models_of_pancreatic_ductal.9.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MPA.0000000000002393" target="_blank" >10.1097/MPA.0000000000002393</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma

Popis výsledku v původním jazyce

Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a 5-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, identification of novel molecular targets, and development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing 3-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.

Název v anglickém jazyce

Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma

Popis výsledku anglicky

Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a 5-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, identification of novel molecular targets, and development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing 3-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pancreas

ISSN

0885-3177

e-ISSN

1536-4828

Svazek periodika

54

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

"e57"-"e71"

Kód UT WoS článku

001375605100003

EID výsledku v databázi Scopus

2-s2.0-85212457568