Assessment of estrogen and progesterone receptors and their combined phenotypes in 287 breast carcinomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000053" target="_blank" >RIV/00209805:_____/99:00000053 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of estrogen and progesterone receptors and their combined phenotypes in 287 breast carcinomas

Popis výsledku v původním jazyce

Using Spearman rank correlation, ER by both methods correlated significantly (p<0,0001), PR weakly (p=0,04). Using thresholds (IHC 10%, LSA: ER 10, PR 15 fmol/mg), concordance was 64% for ER and 53% for PR. As to combined phenotypes, ER + PR+ IHC found ER + PR+ and ER- PR- in 89% tumors, LSA in 66%, ER+ PR- in 10% and 6%, ER- PR+ under 1% and in 28%, respectively. Conclusions: IHC and LSA are comparable for ER, not for PR detection. IHC greatly reduces frequency of imaginary phenotype ER-PR+, thus reflects the ER function better than LSA. IHC appears as method of choice for routine. Nevertheless, LSA can be still useful for research since free receptor fractions may be important in specific biological pathways, e.g. apoptosis.

Název v anglickém jazyce

Assessment of estrogen and progesterone receptors and their combined phenotypes in 287 breast carcinomas

Popis výsledku anglicky

Using Spearman rank correlation, ER by both methods correlated significantly (p<0,0001), PR weakly (p=0,04). Using thresholds (IHC 10%, LSA: ER 10, PR 15 fmol/mg), concordance was 64% for ER and 53% for PR. As to combined phenotypes, ER + PR+ IHC found ER + PR+ and ER- PR- in 89% tumors, LSA in 66%, ER+ PR- in 10% and 6%, ER- PR+ under 1% and in 28%, respectively. Conclusions: IHC and LSA are comparable for ER, not for PR detection. IHC greatly reduces frequency of imaginary phenotype ER-PR+, thus reflects the ER function better than LSA. IHC appears as method of choice for routine. Nevertheless, LSA can be still useful for research since free receptor fractions may be important in specific biological pathways, e.g. apoptosis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

1999

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Breast Cancer Research and Treatment

ISSN

0167-6806

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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