Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A3501" target="_blank" >RIV/00216208:11110/09:3501 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/09:3501

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy

Popis výsledku v původním jazyce

The aim of this study was to determine the changes in the presence and localization of the ?1 ? ?6 collagen IV and ?1, ?2 collagen VIII chains in Czech patients with posterior polymorphous corneal dystrophy (PPCD). Twelve corneal buttons from ten PPCD patients as well as eight control corneas were used and enzymatic indirect immunohistochemistry was performed. More than 50% of PPCD specimens exhibited positivity for ?1 and ?2 collagen IV chains in the basal membrane of the epithelium and in the posterior stroma, while no staining was detected in controls. The ?1 collagen VIII chain was detected on the endothelial and stromal sides of Descemet?s membrane (DM), compared with the prevailing localization on the stromal side of DM in control corneas. The increased expression and the change in localization of the ?1, ?2 collagen IV and ?1 collagen VIII chains may contribute to the increased endothelial proliferative capacity observed in PPCD patients.

Název v anglickém jazyce

Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy

Popis výsledku anglicky

The aim of this study was to determine the changes in the presence and localization of the ?1 ? ?6 collagen IV and ?1, ?2 collagen VIII chains in Czech patients with posterior polymorphous corneal dystrophy (PPCD). Twelve corneal buttons from ten PPCD patients as well as eight control corneas were used and enzymatic indirect immunohistochemistry was performed. More than 50% of PPCD specimens exhibited positivity for ?1 and ?2 collagen IV chains in the basal membrane of the epithelium and in the posterior stroma, while no staining was detected in controls. The ?1 collagen VIII chain was detected on the endothelial and stromal sides of Descemet?s membrane (DM), compared with the prevailing localization on the stromal side of DM in control corneas. The increased expression and the change in localization of the ?1, ?2 collagen IV and ?1 collagen VIII chains may contribute to the increased endothelial proliferative capacity observed in PPCD patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental Eye Research

ISSN

0014-4835

e-ISSN

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Svazek periodika

88

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000265898400011

EID výsledku v databázi Scopus

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