The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A3859" target="_blank" >RIV/00216208:11110/09:3859 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/09:3859

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC

Popis výsledku v původním jazyce

Hodgkin's lymphoma is a lymphoproliferative disease, which differs in its morphology and therapeutic response from other lymphomas. Neoplastic cells represent only a minor cell population of the tumour, while the major part of the tumour is formed by inflammatory cells. It results from the production of cytokines and chemokines both by neoplastic cells and by inflammatory cells. An important prognostic marker in Hodgkin?s lymphoma appears to be the chemokine (C-C motif) ligand 17 (CCL17), also known asthymus and activation-related chemokine (TARC). This chemokine is expressed by many cell types and tissues, and in the case of Hodgkin lymphoma, also by Reed-Sternberg cells. CCL17/TARC binds to chemokine receptors CCR4 and CCR8 and displays chemotacticactivity for T lymphocytes and some other leukocytes. The understanding of biological pathways in Hodgkin?s lymphoma could be important for monitoring of disease activity and for the development of future targeted therapy.

Název v anglickém jazyce

The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC

Popis výsledku anglicky

Hodgkin's lymphoma is a lymphoproliferative disease, which differs in its morphology and therapeutic response from other lymphomas. Neoplastic cells represent only a minor cell population of the tumour, while the major part of the tumour is formed by inflammatory cells. It results from the production of cytokines and chemokines both by neoplastic cells and by inflammatory cells. An important prognostic marker in Hodgkin?s lymphoma appears to be the chemokine (C-C motif) ligand 17 (CCL17), also known asthymus and activation-related chemokine (TARC). This chemokine is expressed by many cell types and tissues, and in the case of Hodgkin lymphoma, also by Reed-Sternberg cells. CCL17/TARC binds to chemokine receptors CCR4 and CCR8 and displays chemotacticactivity for T lymphocytes and some other leukocytes. The understanding of biological pathways in Hodgkin?s lymphoma could be important for monitoring of disease activity and for the development of future targeted therapy.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

110

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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