Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A6853" target="_blank" >RIV/00216208:11110/10:6853 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/10:6853

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis

Popis výsledku v původním jazyce

Cytochrome c oxidase (CcO) is the terminal enzyme of the energy-transducing mitochondrial electron transport chain. It is a hetero-oligomeric complex composed of both mitochondrially and nuclear-encoded subunits. The biogenesis of CcO is sequential process that requires numerous specific accessory proteins, so-called assembly factors, which include translational activators, translocases, molecular chaperones, copper metallochaperones and heme a biosynthetic enzymes. In addition, the correct biogenesis of CcO requires an even greater number of proteins with broader substrate specificities. Indeed, mitochondrial ATP-dependent proteases might play an important role in CcO biogenesis. Out of the four identified energy dependent mitochondrial proteases, three were shown to be involved in proteolysis of CcO subunits. Besides their protein-quality control function these oligomeric complexes may function as molecular chaperones promoting productive folding and assembly of CcO subunits.

Název v anglickém jazyce

Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis

Popis výsledku anglicky

Cytochrome c oxidase (CcO) is the terminal enzyme of the energy-transducing mitochondrial electron transport chain. It is a hetero-oligomeric complex composed of both mitochondrially and nuclear-encoded subunits. The biogenesis of CcO is sequential process that requires numerous specific accessory proteins, so-called assembly factors, which include translational activators, translocases, molecular chaperones, copper metallochaperones and heme a biosynthetic enzymes. In addition, the correct biogenesis of CcO requires an even greater number of proteins with broader substrate specificities. Indeed, mitochondrial ATP-dependent proteases might play an important role in CcO biogenesis. Out of the four identified energy dependent mitochondrial proteases, three were shown to be involved in proteolysis of CcO subunits. Besides their protein-quality control function these oligomeric complexes may function as molecular chaperones promoting productive folding and assembly of CcO subunits.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimica et Biophysica Acta - Bioenergetics

ISSN

0005-2728

e-ISSN

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Svazek periodika

1797

Číslo periodika v rámci svazku

6-7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000279663200066

EID výsledku v databázi Scopus

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