Regulation of Diurnal Variation of Cholesterol 7 alpha-hydroxylase (CYP7A1) Activity in Healthy Subjects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7081" target="_blank" >RIV/00216208:11110/10:7081 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/10:7081

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Regulation of Diurnal Variation of Cholesterol 7 alpha-hydroxylase (CYP7A1) Activity in Healthy Subjects

Popis výsledku v původním jazyce

To better understand the regulation of CYP7A1 activity, three day-long examinations were carried out in 12 healthy men. The concentrations of 7 alpha-hydroxycholest-4-en-3-one (C4), a surrogate marker of CYP7A1 activity, bile acids (BA), insulin, glucose, nonesterified fatty acids, triglycerides, and cholesterol were measured in serum in 90-min intervals from 7 AM till 10 PM. To lower and to increase CYP7A1 activity, the investigations were also performed after cholestyramine or chenodeoxycholic acid administration. Area under the curve of C4 correlated positively with that of insulin.Our results suggest that insulin is involved in the regulation of diurnal variation of CYP7A1 activity in humans.

Název v anglickém jazyce

Regulation of Diurnal Variation of Cholesterol 7 alpha-hydroxylase (CYP7A1) Activity in Healthy Subjects

Popis výsledku anglicky

To better understand the regulation of CYP7A1 activity, three day-long examinations were carried out in 12 healthy men. The concentrations of 7 alpha-hydroxycholest-4-en-3-one (C4), a surrogate marker of CYP7A1 activity, bile acids (BA), insulin, glucose, nonesterified fatty acids, triglycerides, and cholesterol were measured in serum in 90-min intervals from 7 AM till 10 PM. To lower and to increase CYP7A1 activity, the investigations were also performed after cholestyramine or chenodeoxycholic acid administration. Area under the curve of C4 correlated positively with that of insulin.Our results suggest that insulin is involved in the regulation of diurnal variation of CYP7A1 activity in humans.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological research

ISSN

0862-8408

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000278016200010

EID výsledku v databázi Scopus

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