Prognostic Impact of Specific Chromosomal Aberrations in a Large Group of Pediatric Patients With Acute Myeloid Leukemia Treated Uniformly According to Trial AML-BFM 98

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7095" target="_blank" >RIV/00216208:11110/10:7095 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/10:6238 RIV/00064203:_____/10:6238 RIV/00064165:_____/10:7095

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic Impact of Specific Chromosomal Aberrations in a Large Group of Pediatric Patients With Acute Myeloid Leukemia Treated Uniformly According to Trial AML-BFM 98

Popis výsledku v původním jazyce

Data of a large group of patients younger than 18 years treated according to study AML-Berlin-Frankfurt- Munster (BFM) 98 (n = 454), including their cytogenetics, were analyzed. The favorable outcome in the subgroups of patients with t(8;21), inv(16), and t( 15; 17), with an overall survival of 91% (SE,4%), 92% (SE,6%), and 87% (SE,5%), respectively, was confirmed. Within this group, the 5-year probability of event-free survival (pEFS) of all 17 children with t( 8; 21) and additional aberrations apart from del(9q) or -X/-Y was 100%. As expected, the cytogenetic finding of a complex karyotype (n = 35; pEFS, 33%; SE, 8%) or a monosomy 7 (n = 12; pEFS, 17%; SE, 11%) was associated with a poor outcome.

Název v anglickém jazyce

Prognostic Impact of Specific Chromosomal Aberrations in a Large Group of Pediatric Patients With Acute Myeloid Leukemia Treated Uniformly According to Trial AML-BFM 98

Popis výsledku anglicky

Data of a large group of patients younger than 18 years treated according to study AML-Berlin-Frankfurt- Munster (BFM) 98 (n = 454), including their cytogenetics, were analyzed. The favorable outcome in the subgroups of patients with t(8;21), inv(16), and t( 15; 17), with an overall survival of 91% (SE,4%), 92% (SE,6%), and 87% (SE,5%), respectively, was confirmed. Within this group, the 5-year probability of event-free survival (pEFS) of all 17 children with t( 8; 21) and additional aberrations apart from del(9q) or -X/-Y was 100%. As expected, the cytogenetic finding of a complex karyotype (n = 35; pEFS, 33%; SE, 8%) or a monosomy 7 (n = 12; pEFS, 17%; SE, 11%) was associated with a poor outcome.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Oncology

ISSN

0732-183X

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000278108800006

EID výsledku v databázi Scopus

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