A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7144" target="_blank" >RIV/00216208:11110/10:7144 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

Popis výsledku v původním jazyce

Endogenous retroviruses (ERVs) contribute to a range of mutations in mammals. However, autonomous retrotransposition of ERV has not been demonstrated in the rat genome. We cloned an insertion that disrupted Cntrob gene and identified it as a novel endogenous retrovirus (RnERV-K8e family). This family is closely related to the recently reported MmERV-K10c elements. We also identified a novel, unexpectedly close relative of RnERV-K8e in the mouse, suggesting cross-species transmission. We cloned a potentially autonomous RnERV-K8e element demonstrated that it is capable of retrotransposition. This particular element encodes an envelope gene (env), which is not required for retrotransposition. A number of RnERV-K8e-associated genetic polymorphisms was detected among inbred rat strains, suggesting ongoing activity in the rat genome. Ongoing retrotranspositional activity may significantly add to genomic variability among inbred rat strains.

Název v anglickém jazyce

A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains

Popis výsledku anglicky

Endogenous retroviruses (ERVs) contribute to a range of mutations in mammals. However, autonomous retrotransposition of ERV has not been demonstrated in the rat genome. We cloned an insertion that disrupted Cntrob gene and identified it as a novel endogenous retrovirus (RnERV-K8e family). This family is closely related to the recently reported MmERV-K10c elements. We also identified a novel, unexpectedly close relative of RnERV-K8e in the mouse, suggesting cross-species transmission. We cloned a potentially autonomous RnERV-K8e element demonstrated that it is capable of retrotransposition. This particular element encodes an envelope gene (env), which is not required for retrotransposition. A number of RnERV-K8e-associated genetic polymorphisms was detected among inbred rat strains, suggesting ongoing activity in the rat genome. Ongoing retrotranspositional activity may significantly add to genomic variability among inbred rat strains.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genome research

ISSN

1088-9051

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000273249500003

EID výsledku v databázi Scopus

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