The serotonin transporter gene (5-HTT) variant and psychiatric disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8647" target="_blank" >RIV/00216208:11110/10:8647 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/10:8647

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The serotonin transporter gene (5-HTT) variant and psychiatric disorders

Popis výsledku v původním jazyce

Serotonin transporter plays an important role in serotogenic transmisssion and the serotonin transporter gene is under investigation in connection with many psychiatric disorders. There are two main genetic variations in the promoter region of the gene -long (L) allele and a short (S). The S allele is associated with decreased transcriptional efficiency of the promoter leads to reduced serotonin re-uptake in comparison to the long allele which is associated with greater gene expression. The length of polymorphisms are considered to be important mediators of emotional instability and predisposition to mental illness, high trait anxiety, fear-related behavior, negative emotions. The serotonin transporter gene has received much attention in association with psychiatric disorders and its explication can improve understanding to its principles.

Název v anglickém jazyce

The serotonin transporter gene (5-HTT) variant and psychiatric disorders

Popis výsledku anglicky

Serotonin transporter plays an important role in serotogenic transmisssion and the serotonin transporter gene is under investigation in connection with many psychiatric disorders. There are two main genetic variations in the promoter region of the gene -long (L) allele and a short (S). The S allele is associated with decreased transcriptional efficiency of the promoter leads to reduced serotonin re-uptake in comparison to the long allele which is associated with greater gene expression. The length of polymorphisms are considered to be important mediators of emotional instability and predisposition to mental illness, high trait anxiety, fear-related behavior, negative emotions. The serotonin transporter gene has received much attention in association with psychiatric disorders and its explication can improve understanding to its principles.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000288581900002

EID výsledku v databázi Scopus

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