Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9362" target="_blank" >RIV/00216208:11110/11:9362 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/11:9362

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2011.09.015" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2011.09.015</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

Popis výsledku v původním jazyce

The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. Ho

Název v anglickém jazyce

Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

Popis výsledku anglicky

The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. Ho

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

5

Strana od-do

1380-1384

Kód UT WoS článku

000297570300004

EID výsledku v databázi Scopus

—