Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9731" target="_blank" >RIV/00216208:11110/11:9731 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/11:00359262 RIV/00064203:_____/11:7484

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.brainres.2010.11.018" target="_blank" >http://dx.doi.org/10.1016/j.brainres.2010.11.018</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain

Popis výsledku v původním jazyce

It has been found with potassium-selective microelectrodes that the threshold extracellular concentration of potassium [K(+)](e) for eliciting fast spreading depression from the site of administration 1.5 mm away is 80% lower in the rat female cortex (8.0 +/- 0.6 mM) than in the male cortex (14.4 +/- 0.4 mM). The rate of the first slow phase of [K(+)](e) rise before reaching the threshold and speed of SD propagation were similar for both sexes as well as the rise of the second active fast phase of the [K(+)](e) increase. Lower [K(+)](e) threshold in females can facilitate the rapid K(+) release from the nerve tissue cells that may cause a cerebrovascular vasodilatation and the attack of migraine pain. (C) 2010 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain

Popis výsledku anglicky

It has been found with potassium-selective microelectrodes that the threshold extracellular concentration of potassium [K(+)](e) for eliciting fast spreading depression from the site of administration 1.5 mm away is 80% lower in the rat female cortex (8.0 +/- 0.6 mM) than in the male cortex (14.4 +/- 0.4 mM). The rate of the first slow phase of [K(+)](e) rise before reaching the threshold and speed of SD propagation were similar for both sexes as well as the rise of the second active fast phase of the [K(+)](e) increase. Lower [K(+)](e) threshold in females can facilitate the rapid K(+) release from the nerve tissue cells that may cause a cerebrovascular vasodilatation and the attack of migraine pain. (C) 2010 Elsevier B.V. All rights reserved.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/IAA500110905" target="_blank" >IAA500110905: Vylučování acetylcholinu a nikotinový receptor</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Research

ISSN

0006-8993

e-ISSN

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Svazek periodika

1370

Číslo periodika v rámci svazku

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Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

215-219

Kód UT WoS článku

000287065900020

EID výsledku v databázi Scopus

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