Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9925" target="_blank" >RIV/00216208:11110/11:9925 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064165:_____/11:9925
Výsledek na webu
<a href="http://www.sciencedirect.com/science/article/pii/S0891584911004928" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0891584911004928</a>
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice
Popis výsledku v původním jazyce
Heme oxygenase-1 (HO-1) is an antioxidative and cytoprotective enzyme, which may protect neoplastic cells against anticancer therapies, thereby promoting the progression of growing tumors. Our aim was to investigate the role of HO-1 in cancer induction.Experiments were performed in HO-1+/+, HO-1 +/- and HO-1 -/- mice subjected to Chemical induction of squamous cell carcinoma with 7.12-dimethylbenz[a]anthracene and phorbol 12-myristate 13-acetate. Measurements of cytoprotective genes in the livers evidenced systemic oxidative stress in the mice of all the HO-1 genotypes. Carcinogen-induced lesions appeared earlier in H0-1-/- and HO-l+/- than in wild-type animals. They also contained much higher concentrations of vascular endothelial growth factor and keratinocyte chemoattractant, but lower levels of tumor necrosis factor-alpha and interleukin-12. Furthermore, tumors grew much larger in HO-1 knockouts than in the other groups, which was accompanied by an increased rate of animal mortali
Název v anglickém jazyce
Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice
Popis výsledku anglicky
Heme oxygenase-1 (HO-1) is an antioxidative and cytoprotective enzyme, which may protect neoplastic cells against anticancer therapies, thereby promoting the progression of growing tumors. Our aim was to investigate the role of HO-1 in cancer induction.Experiments were performed in HO-1+/+, HO-1 +/- and HO-1 -/- mice subjected to Chemical induction of squamous cell carcinoma with 7.12-dimethylbenz[a]anthracene and phorbol 12-myristate 13-acetate. Measurements of cytoprotective genes in the livers evidenced systemic oxidative stress in the mice of all the HO-1 genotypes. Carcinogen-induced lesions appeared earlier in H0-1-/- and HO-l+/- than in wild-type animals. They also contained much higher concentrations of vascular endothelial growth factor and keratinocyte chemoattractant, but lower levels of tumor necrosis factor-alpha and interleukin-12. Furthermore, tumors grew much larger in HO-1 knockouts than in the other groups, which was accompanied by an increased rate of animal mortali
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FE - Ostatní obory vnitřního lékařství
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Free Radical Biology and Medicine
ISSN
0891-5849
e-ISSN
—
Svazek periodika
51
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
1717-1726
Kód UT WoS článku
000295954600010
EID výsledku v databázi Scopus
—