Weight Gain Is Associated with Medial Contact Site of Subthalamic Stimulation in Parkinson's Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11630" target="_blank" >RIV/00216208:11110/12:11630 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/12:11630 RIV/00023884:_____/12:00007610

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.pone.0038020" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0038020</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Weight Gain Is Associated with Medial Contact Site of Subthalamic Stimulation in Parkinson's Disease

Popis výsledku v původním jazyce

The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson's disease rating scale (UPDRS-III) was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r = -0.55, p<0.01) and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r = -0.42, p<0.01). Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4+/-(SD) 4.4 kg, N = 11) than those with both contacts located laterally (3.9+/-2.7 kg, N = 9) (p<0.001). The position of the active

Název v anglickém jazyce

Weight Gain Is Associated with Medial Contact Site of Subthalamic Stimulation in Parkinson's Disease

Popis výsledku anglicky

The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson's disease rating scale (UPDRS-III) was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r = -0.55, p<0.01) and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r = -0.42, p<0.01). Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4+/-(SD) 4.4 kg, N = 11) than those with both contacts located laterally (3.9+/-2.7 kg, N = 9) (p<0.001). The position of the active

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS One

ISSN

1932-6203

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

"nestrankovano"

Kód UT WoS článku

000305353400069

EID výsledku v databázi Scopus

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