Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12353" target="_blank" >RIV/00216208:11110/12:12353 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/12:12353 RIV/00023728:_____/12:#0004122

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cyto.2012.02.003" target="_blank" >http://dx.doi.org/10.1016/j.cyto.2012.02.003</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

Popis výsledku v původním jazyce

Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and characterise its potential association with skin changes and SSc-related features.Adiponectin serum levels were similar between patients with SSc and healthy controls. Levels of serum adiponectin were negatively correlated with the skin score. Regression analysis of the relationship between adiponectin and markers of interest provided two statistically significant models: A- with explanatory variables HDL-cholesterol, skin score, disease duration, age (R(2)=0.580); and B- with CRP, skin score, age in order of a decreasing influence. Based on the results of this study, it might be speculated that adiponectin plays a protective role in ski

Název v anglickém jazyce

Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

Popis výsledku anglicky

Adiponectin was initially described as a regulator of metabolic homeostases. Further studies demonstrated its involvement in the regulation of inflammatory diseases, particularly rheumatic and vascular diseases and some fibrotic processes. The aim of this study was to evaluate adiponectin in the circulation of patients with systemic sclerosis (SSc) and characterise its potential association with skin changes and SSc-related features.Adiponectin serum levels were similar between patients with SSc and healthy controls. Levels of serum adiponectin were negatively correlated with the skin score. Regression analysis of the relationship between adiponectin and markers of interest provided two statistically significant models: A- with explanatory variables HDL-cholesterol, skin score, disease duration, age (R(2)=0.580); and B- with CRP, skin score, age in order of a decreasing influence. Based on the results of this study, it might be speculated that adiponectin plays a protective role in ski

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytokine

ISSN

1043-4666

e-ISSN

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Svazek periodika

58

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

165-168

Kód UT WoS článku

000303099200006

EID výsledku v databázi Scopus

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