NEUROPEPTIDE OXYTOCIN IS ALSO SYNTHESIZED IN THE HEART UNDER BASAL AS WELL AS STRESS CONDITIONS AND FUNCTIONS AS A NEW CARDIOVASCULAR HORMONE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12386" target="_blank" >RIV/00216208:11110/12:12386 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

NEUROPEPTIDE OXYTOCIN IS ALSO SYNTHESIZED IN THE HEART UNDER BASAL AS WELL AS STRESS CONDITIONS AND FUNCTIONS AS A NEW CARDIOVASCULAR HORMONE

Popis výsledku v původním jazyce

Our results contribute to the idea of oxytocin functioning as a cardiovascular hormone. Expression of OTR mRNA and immunohistochemical detection of OTR in all heart compartments indicate that oxytocin system plays an important regulatory role in the cardiovascular system both under basal and stress conditions. The distribution of oxytocin and its receptors in the heart, and in some cases their colocalization with nuclei are new findings, which can explain some controversial findings like quantitative discrepancy in expression of OTR mRNA and expression of OTR receptor protein. These findings require further studies and it can be expected that they will help to find target structures for therapeutic interventions.

Název v anglickém jazyce

NEUROPEPTIDE OXYTOCIN IS ALSO SYNTHESIZED IN THE HEART UNDER BASAL AS WELL AS STRESS CONDITIONS AND FUNCTIONS AS A NEW CARDIOVASCULAR HORMONE

Popis výsledku anglicky

Our results contribute to the idea of oxytocin functioning as a cardiovascular hormone. Expression of OTR mRNA and immunohistochemical detection of OTR in all heart compartments indicate that oxytocin system plays an important regulatory role in the cardiovascular system both under basal and stress conditions. The distribution of oxytocin and its receptors in the heart, and in some cases their colocalization with nuclei are new findings, which can explain some controversial findings like quantitative discrepancy in expression of OTR mRNA and expression of OTR receptor protein. These findings require further studies and it can be expected that they will help to find target structures for therapeutic interventions.

Druh

D - Stať ve sborníku

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

9th International Medical Postgraduate Conference New Frontiers in the Research of PhD Students

ISBN

978-80-260-3373-8

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

86-89

Název nakladatele

Charles University in Prague,Faculty of Medicine in Hradec Králové

Místo vydání

Hradec Králové

Místo konání akce

Hradec Králové, ČR

Datum konání akce

22. 11. 2012

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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