Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12394" target="_blank" >RIV/00216208:11110/12:12394 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/12:#0000218 RIV/00064165:_____/12:12394 RIV/00023728:_____/12:#0004140

Výsledek na webu

<a href="http://dx.doi.org/10.1530/EJE-11-1047" target="_blank" >http://dx.doi.org/10.1530/EJE-11-1047</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence

Popis výsledku v původním jazyce

Background: The aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents. Methods: In thisprospective crossover study, 56 healthy females (15-19.5 years) with desire to use hormonal contraception were randomized to COC with either 30 or 15 mu g of EE in crossover design of 9-month intervention each in reverse order. Nonusers of the same age (n=28) served as controls. BMD at lumbar spine (LS), total femur, femoral neck, distal radius, and total body, and serum markers (N-propeptide of type I procollagen, and type I collagen C-telopeptide) were measured at baseline and after 9 and 18 months. Results: In COC nonusers, BMD significantly increased at LS and radius, while markers decreased. In COC users, BMD did not increase, with the exception of LS BMD in the 30 mu g COC group (P<0.05). In the crossover design, a difference betw

Název v anglickém jazyce

Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence

Popis výsledku anglicky

Background: The aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents. Methods: In thisprospective crossover study, 56 healthy females (15-19.5 years) with desire to use hormonal contraception were randomized to COC with either 30 or 15 mu g of EE in crossover design of 9-month intervention each in reverse order. Nonusers of the same age (n=28) served as controls. BMD at lumbar spine (LS), total femur, femoral neck, distal radius, and total body, and serum markers (N-propeptide of type I procollagen, and type I collagen C-telopeptide) were measured at baseline and after 9 and 18 months. Results: In COC nonusers, BMD significantly increased at LS and radius, while markers decreased. In COC users, BMD did not increase, with the exception of LS BMD in the 30 mu g COC group (P<0.05). In the crossover design, a difference betw

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Endocrinology

ISSN

0804-4643

e-ISSN

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Svazek periodika

166

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1003-1011

Kód UT WoS článku

000304541100006

EID výsledku v databázi Scopus

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