Pressure Overload Selectively Increases n-3 PUFA in Myocardial Phospholipids During Early Postnatal Period
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12535" target="_blank" >RIV/00216208:11110/12:12535 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/12:00381020 RIV/00216208:11310/12:10130397
Výsledek na webu
<a href="http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%201/61_S155.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/61%20Suppl%201/61_S155.pdf</a>
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Pressure Overload Selectively Increases n-3 PUFA in Myocardial Phospholipids During Early Postnatal Period
Popis výsledku v původním jazyce
Increasing hemodynamic load during early postnatal development leads to rapid growth of the left ventricular (LV) myocardium, which is associated with membrane phospholipid (PL) remodeling characterized by n-3 polyunsaturated fatty acids (PUFA) accumulation. The aim of this study was to examine the influence of additional workload imposed early after birth when ventricular myocytes are still able to proliferate. Male Wistar rats were subjected to abdominal aortic constriction (AC) at postnatal day 2. Concentrations of PL and their fatty acid (FA) profiles in the LV were analyzed in AC, sham-operated (SO) and intact animals on postnatal days 2 (intact only), 5 and 10. AC resulted in LV enlargement by 22 % and 67 % at days 5 and 10, respectively, compared with age-matched SO littermates. Concentrations of phosphatidylcholine, cardiolipin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine and sph ngomyelin decreased in AC myocardium, albeit with different time course and
Název v anglickém jazyce
Pressure Overload Selectively Increases n-3 PUFA in Myocardial Phospholipids During Early Postnatal Period
Popis výsledku anglicky
Increasing hemodynamic load during early postnatal development leads to rapid growth of the left ventricular (LV) myocardium, which is associated with membrane phospholipid (PL) remodeling characterized by n-3 polyunsaturated fatty acids (PUFA) accumulation. The aim of this study was to examine the influence of additional workload imposed early after birth when ventricular myocytes are still able to proliferate. Male Wistar rats were subjected to abdominal aortic constriction (AC) at postnatal day 2. Concentrations of PL and their fatty acid (FA) profiles in the LV were analyzed in AC, sham-operated (SO) and intact animals on postnatal days 2 (intact only), 5 and 10. AC resulted in LV enlargement by 22 % and 67 % at days 5 and 10, respectively, compared with age-matched SO littermates. Concentrations of phosphatidylcholine, cardiolipin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine and sph ngomyelin decreased in AC myocardium, albeit with different time course and
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
—
Svazek periodika
61
Číslo periodika v rámci svazku
Suppl.1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
9
Strana od-do
"S155"-"S163"
Kód UT WoS článku
000307133700012
EID výsledku v databázi Scopus
—