Specific Cooperation Between Imp-alpha 2 and Imp-beta/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12788" target="_blank" >RIV/00216208:11110/12:12788 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1534/g3.111.001073" target="_blank" >http://dx.doi.org/10.1534/g3.111.001073</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Specific Cooperation Between Imp-alpha 2 and Imp-beta/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions

Popis výsledku v původním jazyce

The multifunctional factors Imp-alpha and Imp-beta are involved in nuclear protein import, mitotic spindle dynamics, and nuclear membrane formation. Furthermore, each of the three members of the Imp-alpha family exerts distinct tasks during development.In Drosophila melanogaster, the imp-alpha 2 gene is critical during oogenesis for ring canal assembly; specific mutations, which allow oogenesis to proceed normally, were found to block early embryonic mitosis. Here, we show that imp-alpha 2 and imp-betagenetically interact during early embryonic development, and we characterize the pattern of defects affecting mitosis in embryos laid by heterozygous imp-alpha 2(D14) and imp-beta(KetRE34) females. Embryonic development is arrested in these embryos butis unaffected in combinations between imp-beta(KetRE34) and null mutations in imp-alpha 1 or imp-alpha 3. Furthermore, the imp-alpha 2(D14)/imp-beta(KetRE34) interaction could only be rescued by an imp-alpha 2 transgene, albeit not imp-al

Název v anglickém jazyce

Specific Cooperation Between Imp-alpha 2 and Imp-beta/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions

Popis výsledku anglicky

The multifunctional factors Imp-alpha and Imp-beta are involved in nuclear protein import, mitotic spindle dynamics, and nuclear membrane formation. Furthermore, each of the three members of the Imp-alpha family exerts distinct tasks during development.In Drosophila melanogaster, the imp-alpha 2 gene is critical during oogenesis for ring canal assembly; specific mutations, which allow oogenesis to proceed normally, were found to block early embryonic mitosis. Here, we show that imp-alpha 2 and imp-betagenetically interact during early embryonic development, and we characterize the pattern of defects affecting mitosis in embryos laid by heterozygous imp-alpha 2(D14) and imp-beta(KetRE34) females. Embryonic development is arrested in these embryos butis unaffected in combinations between imp-beta(KetRE34) and null mutations in imp-alpha 1 or imp-alpha 3. Furthermore, the imp-alpha 2(D14)/imp-beta(KetRE34) interaction could only be rescued by an imp-alpha 2 transgene, albeit not imp-al

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP302%2F11%2F1640" target="_blank" >GAP302/11/1640: Morfologické znaky a molekulární determinanty apokrinní sekrece</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

G3-GENES GENOMES GENETICS

ISSN

2160-1836

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

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EID výsledku v databázi Scopus

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